Department of Medical Neurobiology, Institute of Medical Research Israel-Canada (IMRIC), The Hebrew University-Hadassah Medical School, Jerusalem, Israel.
The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.
Nat Commun. 2021 Dec 2;12(1):7026. doi: 10.1038/s41467-021-27375-5.
Βeta oscillatory activity (human: 13-35 Hz; primate: 8-24 Hz) is pervasive within the cortex and basal ganglia. Studies in Parkinson's disease patients and animal models suggest that beta-power increases with dopamine depletion. However, the exact relationship between oscillatory power, frequency and dopamine tone remains unclear. We recorded neural activity in the cortex and basal ganglia of healthy non-human primates while acutely and chronically up- and down-modulating dopamine levels. We assessed changes in beta oscillations in patients with Parkinson's following acute and chronic changes in dopamine tone. Here we show beta oscillation frequency is strongly coupled with dopamine tone in both monkeys and humans. Power, coherence between single-units and local field potentials (LFP), spike-LFP phase-locking, and phase-amplitude coupling are not systematically regulated by dopamine levels. These results demonstrate that beta frequency is a key property of pathological oscillations in cortical and basal ganglia networks.
β 振荡活动（人类：13-35 Hz；灵长类动物：8-24 Hz）普遍存在于皮质和基底节中。帕金森病患者和动物模型的研究表明，β 功率随多巴胺耗竭而增加。然而，振荡功率、频率和多巴胺张力之间的确切关系仍不清楚。我们在急性和慢性调节多巴胺水平的情况下，记录了健康非人类灵长类动物皮质和基底节的神经活动。我们评估了帕金森病患者在多巴胺张力急性和慢性变化后的β 振荡变化。在这里，我们表明β 振荡频率与猴子和人类的多巴胺张力密切相关。功率、单个单元和局部场电位（LFP）之间的相干性、尖峰-LFP 相位锁定和相位-幅度耦合不受多巴胺水平的系统调节。这些结果表明，β 频率是皮质和基底节网络病理性振荡的关键特性。
