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调制多巴胺能活动可引起皮质-基底节β节律的频率漂移。

Modulation of dopamine tone induces frequency shifts in cortico-basal ganglia beta oscillations.

机构信息

Department of Medical Neurobiology, Institute of Medical Research Israel-Canada (IMRIC), The Hebrew University-Hadassah Medical School, Jerusalem, Israel.

The Edmond and Lily Safra Center for Brain Sciences, The Hebrew University of Jerusalem, Jerusalem, Israel.

出版信息

Nat Commun. 2021 Dec 2;12(1):7026. doi: 10.1038/s41467-021-27375-5.

DOI:10.1038/s41467-021-27375-5
PMID:34857767
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8640051/
Abstract

Βeta oscillatory activity (human: 13-35 Hz; primate: 8-24 Hz) is pervasive within the cortex and basal ganglia. Studies in Parkinson's disease patients and animal models suggest that beta-power increases with dopamine depletion. However, the exact relationship between oscillatory power, frequency and dopamine tone remains unclear. We recorded neural activity in the cortex and basal ganglia of healthy non-human primates while acutely and chronically up- and down-modulating dopamine levels. We assessed changes in beta oscillations in patients with Parkinson's following acute and chronic changes in dopamine tone. Here we show beta oscillation frequency is strongly coupled with dopamine tone in both monkeys and humans. Power, coherence between single-units and local field potentials (LFP), spike-LFP phase-locking, and phase-amplitude coupling are not systematically regulated by dopamine levels. These results demonstrate that beta frequency is a key property of pathological oscillations in cortical and basal ganglia networks.

摘要

β 振荡活动（人类：13-35 Hz；灵长类动物：8-24 Hz）普遍存在于皮质和基底节中。帕金森病患者和动物模型的研究表明，β 功率随多巴胺耗竭而增加。然而，振荡功率、频率和多巴胺张力之间的确切关系仍不清楚。我们在急性和慢性调节多巴胺水平的情况下，记录了健康非人类灵长类动物皮质和基底节的神经活动。我们评估了帕金森病患者在多巴胺张力急性和慢性变化后的β 振荡变化。在这里，我们表明β 振荡频率与猴子和人类的多巴胺张力密切相关。功率、单个单元和局部场电位（LFP）之间的相干性、尖峰-LFP 相位锁定和相位-幅度耦合不受多巴胺水平的系统调节。这些结果表明，β 频率是皮质和基底节网络病理性振荡的关键特性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7741/8640051/e17dd471f085/41467_2021_27375_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7741/8640051/7242fb2d7a81/41467_2021_27375_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7741/8640051/21559f8db545/41467_2021_27375_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7741/8640051/b2e0688f4ce3/41467_2021_27375_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7741/8640051/a42bb48f74c6/41467_2021_27375_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7741/8640051/b2dba4b255ab/41467_2021_27375_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7741/8640051/c62f2cd42516/41467_2021_27375_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7741/8640051/eeb1b9695e21/41467_2021_27375_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7741/8640051/ea86ca1e67ee/41467_2021_27375_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7741/8640051/e17dd471f085/41467_2021_27375_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7741/8640051/7242fb2d7a81/41467_2021_27375_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7741/8640051/21559f8db545/41467_2021_27375_Fig2_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7741/8640051/b2e0688f4ce3/41467_2021_27375_Fig3_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7741/8640051/a42bb48f74c6/41467_2021_27375_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7741/8640051/b2dba4b255ab/41467_2021_27375_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7741/8640051/c62f2cd42516/41467_2021_27375_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7741/8640051/eeb1b9695e21/41467_2021_27375_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7741/8640051/ea86ca1e67ee/41467_2021_27375_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7741/8640051/e17dd471f085/41467_2021_27375_Fig9_HTML.jpg

相似文献

[1]
Modulation of dopamine tone induces frequency shifts in cortico-basal ganglia beta oscillations.

Nat Commun. 2021-12-2

[2]
Short- and long-term dopamine depletion causes enhanced beta oscillations in the cortico-basal ganglia loop of parkinsonian rats.

Exp Neurol. 2016-10-12

[3]
Changes in neuronal activity of cortico-basal ganglia-thalamic networks induced by acute dopaminergic manipulations in rats.

Eur J Neurosci. 2018-1-18

[4]
Ventral Medial Thalamic Nucleus Promotes Synchronization of Increased High Beta Oscillatory Activity in the Basal Ganglia-Thalamocortical Network of the Hemiparkinsonian Rat.

J Neurosci. 2016-4-13

[5]
Propagation of beta/gamma rhythms in the cortico-basal ganglia circuits of the parkinsonian rat.

J Neurophysiol. 2018-5-1

[6]
Beta synchrony in the cortico-basal ganglia network during regulation of force control on and off dopamine.

Neurobiol Dis. 2019-3-6

[7]
Functional correlates of exaggerated oscillatory activity in basal ganglia output in hemiparkinsonian rats.

Exp Neurol. 2014-11

[8]
Spike synchronization in the cortex/basal-ganglia networks of Parkinsonian primates reflects global dynamics of the local field potentials.

J Neurosci. 2004-6-30

[9]
Bilateral functional connectivity of the basal ganglia in patients with Parkinson's disease and its modulation by dopaminergic treatment.

PLoS One. 2013-12-20

[10]
The role of coupling connections in a model of the cortico-basal ganglia-thalamocortical neural loop for the generation of beta oscillations.

Neural Netw. 2019-12-30

引用本文的文献

[1]
Enhanced beta power emerges from simulated parkinsonian primary motor cortex.

NPJ Parkinsons Dis. 2025-8-5

[2]
Changes in sensorimotor network dynamics in resting-state recordings in Parkinson's disease.

Brain Commun. 2025-7-23

[3]
Longitudinal changes of resting-state networks in Parkinson's disease.

Neuroimage Clin. 2025-6-25

[4]
Decreased cellular excitability of pyramidal tract neurons in primary motor cortex leads to paradoxically increased network activity in simulated parkinsonian motor cortex.

Res Sq. 2025-4-11

[5]
Shared pathway-specific network mechanisms of dopamine and deep brain stimulation for the treatment of Parkinson's disease.

Nat Commun. 2025-4-15

[6]
Emergent Aspects of the Integration of Sensory and Motor Functions.

Brain Sci. 2025-2-7

[7]
Reduced Modulation of Theta and Beta Oscillations Mediates Empathy Impairment in Parkinson's Disease.

Brain Behav. 2025-2

[8]
Electrophysiological Alterations in the Progression of Parkinson's Disease and the Therapeutic Effect of Tetrabenazine on Rats With Levodopa-Induced Dyskinesia.

CNS Neurosci Ther. 2025-2

[9]
Dopamine facilitates the response to glutamatergic inputs in astrocyte cell models.

PLoS Comput Biol. 2024-12-16

[10]
Cortical beta oscillations map to shared brain networks modulated by dopamine.

Elife. 2024-12-4

本文引用的文献

[1]
Classification of Cortical Neurons by Spike Shape and the Identification of Pyramidal Neurons.

Cereb Cortex. 2021-10-1

[2]
Gait-related frequency modulation of beta oscillatory activity in the subthalamic nucleus of parkinsonian patients.

Brain Stimul. 2020

[3]
Frequency-Specific Optogenetic Deep Brain Stimulation of Subthalamic Nucleus Improves Parkinsonian Motor Behaviors.

J Neurosci. 2020-4-20

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Microinjectrode System for Combined Drug Infusion and Electrophysiology.

J Vis Exp. 2019-11-13

[5]
Motor Cortex Inputs at the Optimum Phase of Beta Cortical Oscillations Undergo More Rapid and Less Variable Corticospinal Propagation.

J Neurosci. 2019-11-21

[6]
Quantification of Phase-Amplitude Coupling in Neuronal Oscillations: Comparison of Phase-Locking Value, Mean Vector Length, Modulation Index, and Generalized-Linear-Modeling-Cross-Frequency-Coupling.

Front Neurosci. 2019-6-7

[7]
Synchronised spiking activity underlies phase amplitude coupling in the subthalamic nucleus of Parkinson's disease patients.

Neurobiol Dis. 2019-2-10

[8]
Longer β oscillatory episodes reliably identify pathological subthalamic activity in Parkinsonism.

Mov Disord. 2018-8-25

[9]
Subthalamic theta activity: a novel human subcortical biomarker for obsessive compulsive disorder.

Transl Psychiatry. 2018-6-18

[10]
Pallidal Deep-Brain Stimulation Disrupts Pallidal Beta Oscillations and Coherence with Primary Motor Cortex in Parkinson's Disease.

J Neurosci. 2018-4-16

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