Sure Matthias, Hyder Rasha, Kandemir Levent, Vesper Jan, Schnitzler Alfons, Florin Esther
Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University Düsseldorf, Germany; Bielefeld University, Medical School and University Medical Center OWL, Klinikum Lippe, University Institute for Laboratory Medicine, Microbiology and Clinical Pathobiochemistry, Detmold, Germany.
Institute of Clinical Neuroscience and Medical Psychology, Medical Faculty, Heinrich Heine University Düsseldorf, Germany; Cardiff University Brain Research Imaging Centre (CUBRIC), School of Psychology, Cardiff University, United Kingdom.
Neuroimage Clin. 2025 Jun 25;47:103833. doi: 10.1016/j.nicl.2025.103833.
Deep brain stimulation (DBS), but also the sole implantation of the electrodes and dopaminergic medication, can reduce symptoms in Parkinson's disease (PD) patients. Furthermore, an effect on network activity is known for all three options separately. However, long-term effects have rarely been investigated. Therefore, in the present study, we focus on the long-term impact of dopaminergic medication on whole-brain network activity following DBS electrode implantation. Therefore, we extracted resting state networks (RSNs) of 20 PD patients (4 females, (59.00 ± 9.72 years) from magnetoencephalography data. We recorded 30 min of resting-state activity two days before and one year after implantation of the electrodes with and without dopaminergic medication, but DBS was turned off. RSNs were obtained based on the phase-amplitude coupling between a low-frequency phase and a high gamma amplitude and examined for differences between conditions (i.e., pre- vs. post-surgery). We identified three RSNs across all conditions: sensory-motor, visual, and frontal. Each RSN was selectively altered due to a year of disease progression - while patients being treated with dopaminergic medication and DBS. In line with previous literature, we focus on longitudinal changes in RSNs over time after electrode implantation, acknowledging that chronic DBS treatment and other factors may confound the interpretation of these changes. In addition, the alterations found were RSN specific, as dopaminergic medication showed a greater impact on the frontal RSN, and the longitudinal factor expressed by the disease progression was more severe in alterations in the SMN and the visual RSN.
深部脑刺激（DBS），以及单纯的电极植入和多巴胺能药物治疗，均可减轻帕金森病（PD）患者的症状。此外，已知这三种治疗方式分别对网络活动有影响。然而，长期影响却鲜有研究。因此，在本研究中，我们聚焦于多巴胺能药物治疗对DBS电极植入后全脑网络活动的长期影响。为此，我们从20例PD患者（4名女性，年龄59.00 ± 9.72岁）的脑磁图数据中提取静息态网络（RSN）。我们在电极植入前和植入后一年，分别在服用和未服用多巴胺能药物但DBS关闭状态下，记录了30分钟的静息态活动。基于低频相位和高伽马波幅之间的相位 - 振幅耦合获得RSN，并检查不同条件（即术前与术后）之间的差异。我们在所有条件下识别出三个RSN：感觉运动、视觉和额叶。在患者接受多巴胺能药物治疗和DBS的情况下，由于疾病进展一年，每个RSN都有选择性地发生了改变。与先前的文献一致，我们关注电极植入后RSN随时间的纵向变化，同时认识到慢性DBS治疗和其他因素可能会混淆这些变化结果的解释。此外，所发现的改变具有RSN特异性，因为多巴胺能药物对额叶RSN的影响更大，而疾病进展所表现出的纵向因素在感觉运动网络（SMN）和视觉RSN的改变中更为严重。
