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病例报告：不明原发癌的组织起源鉴定：基因表达谱分析方法。

Case Report: Tissue Origin Identification for Cancer of Unknown Primary: Gene Expression Profiling Approach.

作者信息

Pu Xingxiang, Yang Sa, Xu Yan, Chen Bolin, Wang Qianzhi, Gong Qian, Wu Lin

机构信息

Department of Thoracic Medical Oncology, Hunan Cancer Hospital/The Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, China.

Department of Pharmacy, Xiangxiang People's Hospital, Xiangxiang, China.

出版信息

Front Oncol. 2021 Nov 11;11:702887. doi: 10.3389/fonc.2021.702887. eCollection 2021.

DOI:10.3389/fonc.2021.702887
PMID:34858803
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8632144/
Abstract

The treatment of cancer of unknown primary (CUP) is a huge challenge for clinicians. Gene expression profiling can help identify the tissue origin of tumors by detecting the expression levels of specific genes in tumor tissues. Herein, we report four CUP cases. All of them have been successfully identified with the corresponding primary tumor sites through gene expression profiling analysis. Then all patients received accurate treatment, providing reference to guide therapeutic decisions to treat CUP tumors in the future.

摘要

原发灶不明癌症（CUP）的治疗对临床医生来说是一项巨大挑战。基因表达谱分析可通过检测肿瘤组织中特定基因的表达水平来帮助识别肿瘤的组织起源。在此，我们报告4例CUP病例。通过基因表达谱分析，所有病例均成功确定了相应的原发肿瘤部位。随后所有患者均接受了精准治疗，为未来指导CUP肿瘤的治疗决策提供了参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0c/8632144/aa3e8705029b/fonc-11-702887-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0c/8632144/faa83dc93bf5/fonc-11-702887-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0c/8632144/b8da6fe9bd57/fonc-11-702887-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0c/8632144/dada034eea5d/fonc-11-702887-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0c/8632144/aa3e8705029b/fonc-11-702887-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0c/8632144/faa83dc93bf5/fonc-11-702887-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0c/8632144/b8da6fe9bd57/fonc-11-702887-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0c/8632144/dada034eea5d/fonc-11-702887-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd0c/8632144/aa3e8705029b/fonc-11-702887-g004.jpg

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引用本文的文献

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本文引用的文献

1
Site-Specific and Targeted Therapy Based on Molecular Profiling by Next-Generation Sequencing for Cancer of Unknown Primary Site: A Nonrandomized Phase 2 Clinical Trial.基于下一代测序的分子谱分析的不明原发部位癌的局部治疗和靶向治疗：一项非随机 2 期临床试验。
JAMA Oncol. 2020 Dec 1;6(12):1931-1938. doi: 10.1001/jamaoncol.2020.4643.
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Development and Clinical Validation of a 90-Gene Expression Assay for Identifying Tumor Tissue Origin.用于鉴定肿瘤组织来源的 90 基因表达检测试剂盒的开发和临床验证。
J Mol Diagn. 2020 Sep;22(9):1139-1150. doi: 10.1016/j.jmoldx.2020.06.005. Epub 2020 Jun 28.
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Site-specific Chemotherapy Based on Predicted Primary Site by Pathological Profile for Carcinoma of Unknown Primary Site.
基于病理特征预测原发部位的不明原发癌的肿瘤特异性化疗。
Clin Oncol (R Coll Radiol). 2018 Oct;30(10):667-673. doi: 10.1016/j.clon.2018.06.012. Epub 2018 Jul 6.
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Epigenetic profiling to classify cancer of unknown primary: a multicentre, retrospective analysis.基于表观遗传学特征对不明原发灶癌进行分类：一项多中心、回顾性分析。
Lancet Oncol. 2016 Oct;17(10):1386-1395. doi: 10.1016/S1470-2045(16)30297-2. Epub 2016 Aug 27.
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Cancer of unknown primary site.原发部位不明的癌症。
N Engl J Med. 2014 Aug 21;371(8):757-65. doi: 10.1056/NEJMra1303917.
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Uncertainty and anxiety in the cancer of unknown primary patient journey: a multiperspective qualitative study.未知原发癌患者就医过程中的不确定性与焦虑：一项多视角定性研究
BMJ Support Palliat Care. 2015 Dec;5(4):366-72. doi: 10.1136/bmjspcare-2013-000482. Epub 2013 Nov 19.
7
Molecular gene expression profiling to predict the tissue of origin and direct site-specific therapy in patients with carcinoma of unknown primary site: a prospective trial of the Sarah Cannon research institute.采用分子基因表达谱分析预测原发灶不明的癌患者的组织来源和直接靶向特定部位的治疗：萨拉·坎农研究所的一项前瞻性试验。
J Clin Oncol. 2013 Jan 10;31(2):217-23. doi: 10.1200/JCO.2012.43.3755. Epub 2012 Oct 1.
8
Cancer of unknown primary (CUP).原发灶不明的癌症（CUP）。
Crit Rev Oncol Hematol. 2005 Jun;54(3):243-50. doi: 10.1016/j.critrevonc.2004.10.002.