Engineering Faculty, Universiti Malaysia Sabah, Jalan UMS, 88400 Kota Kinabalu, Sabah, Malaysia.
Pusat Persediaan Sains dan Teknologi, Universiti Malaysia Sabah, Jalan UMS, 88400 Kota Kinabalu, Sabah, Malaysia.
Biomed Res Int. 2021 Nov 23;2021:6173143. doi: 10.1155/2021/6173143. eCollection 2021.
Potential antibacterial substances, such as titanium dioxide (TiO), are being extensively studied throughout the research world. A modified hydrothermal nanotitania extraction was shown to inhibit growth in the laboratory. However, the toxicity effect of the extract on rats is unknown. In this study, we observed the effects of a modified hydrothermal nanotitania extraction on the skin and behavior of Sprague-Dawley rats.
Sprague-Dawley () rats were used as the experimental animals. The skin around the dorsum of the tested animals was shaved and pasted with 0.1 mg and 0.5 mg of the nanotitania extraction. The color and condition of the pasted area and the behavior of the animals were observed.
0.1 mg nanotitania extraction application on the dorsum of the rat produced no skin color changes at day 1, day 3, day 5, or day 7 postapplication. There were no changes in their behavior up to day 7 with no skin rashes or skin scratches seen or fur changes. However, 0.5 mg of nanotitania extraction resulted in redness and less fur regrowth at day 7.
A 0.1 mg modified nanotitania extraction was observed to have no effect on the skin of Sprague-Dawley rats.
研究人员正在广泛研究具有潜在抗菌作用的物质，如二氧化钛（TiO）。研究表明，改良的水热纳米二氧化钛提取法可抑制 生长。然而，这种提取物对大鼠的毒性作用尚不清楚。在这项研究中，我们观察了改良水热纳米二氧化钛提取法对 Sprague-Dawley 大鼠皮肤和行为的影响。
以 Sprague-Dawley（SD）大鼠为实验动物。用 0.1mg 和 0.5mg 纳米二氧化钛提取物涂抹受试动物背部皮肤，观察涂抹区域皮肤颜色和状况及动物行为。
第 1、3、5 和 7 天，0.1mg 纳米二氧化钛提取物涂抹在大鼠背部未引起皮肤颜色变化。7 天内动物行为没有变化，没有出现皮疹、皮肤抓痕或毛发变化。然而，0.5mg 纳米二氧化钛提取物导致第 7 天皮肤变红，毛发再生减少。
观察到 0.1mg 改良纳米二氧化钛提取物对 Sprague-Dawley 大鼠皮肤无影响。
