State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Huaxi MR Research Center, Dept. of Radiology, West China Hospital of Sichuan University, Chengdu 610041, China.
Hua Xi Kou Qiang Yi Xue Za Zhi. 2021 Dec 1;39(6):682-689. doi: 10.7518/hxkq.2021.06.009.
This study was conducted to investigate the brain function of patients with temporomandibular disorders (TMD) by combining the static and dynamic amplitudes of low-frequency fluctuation (ALFF).
Thirty patients with TMD and 20 healthy controls were enrolled. All the participants completed their questionnaires, received clinical examinations, and underwent resting-state functional magnetic resonance imaging scanning. We compared the static and dynamic ALFF between the patients and healthy controls by conducting a two-sample -test with AlphaSim correction for multiple comparisons. The correlation between the static and dynamic ALFF of the brain regions with significant group differences and clinical measurements was analyzed.
The patients with TMD showed increased static and dynamic ALFF in the posterior cingulate cortex compared with that of the controls (whole-brain level, uncorrected =0.005; region of interest level with AlphaSim correction, voxel level <0.005, cluster level <0.05). The dynamic ALFF of the posterior cingulate cortex was negatively correlated with bilateral condylar vertical discrepancies. The dynamic ALFF in the medial orbitofrontal cortex of the patients with TMD was greater than that of the controls (whole-brain level AlphaSim correction, voxel level <0.005, cluster level <0.05).
Our findings revealed that the resting-state brain function of the posterior cingulate cortex and the medial orbitofrontal cortex of patient with TMD increased. These changes probably indicated the potential central mechanisms underlying the increased self-relevant thoughts, negative emotion, and abnormal emotion regulation in TMD.
本研究通过结合低频振幅的静态和动态幅度来研究颞下颌关节紊乱病（TMD）患者的大脑功能。
纳入 30 名 TMD 患者和 20 名健康对照者。所有参与者均完成问卷、接受临床检查和静息态功能磁共振成像扫描。我们通过双样本 t 检验和 AlphaSim 校正进行多重比较，比较了患者和健康对照组之间的静态和动态低频振幅。分析了具有显著组间差异和临床测量值的脑区静态和动态低频振幅之间的相关性。
与对照组相比，TMD 患者的后扣带回皮质显示出静态和动态低频振幅增加（全脑水平，未校正=0.005；感兴趣区水平，经 AlphaSim 校正，体素水平<0.005，簇水平<0.05）。后扣带回皮质的动态低频振幅与双侧髁突垂直差异呈负相关。TMD 患者的内侧眶额皮质的动态低频振幅大于对照组（全脑水平，经 AlphaSim 校正，体素水平<0.005，簇水平<0.05）。
我们的发现表明，TMD 患者的后扣带回皮质和内侧眶额皮质的静息状态大脑功能增加。这些变化可能表明 TMD 中自我相关思维、负性情绪和异常情绪调节增加的潜在中枢机制。
