Wu Min, Zhu Zhi Bing, Shi Bing, Gong Cai Xia, Li Yang
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Cleft Lip and Palate Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China.
Hua Xi Kou Qiang Yi Xue Za Zhi. 2021 Dec 1;39(6):709-711. doi: 10.7518/hxkq.2021.06.013.
To study the effect of preoperative prophylactic use of antibiotics on wound infection in patients with cleft lip.
Aretrospective study was conducted on the clinical data of 1 361 patients who underwent one-stage cleft lip repair in the Department of Cleft Lip and Palate in West China Hospital of Stomatology, Sichuan University, from January 2015 to November 2018. The patients were divided into two groups according to whether prophylactic antibiotics were used or not. There were 594 patients in the prevention group, including 373 unilateral incomplete cleft lip (UICL) patients, 157 unilateral complete cleft lip (UCCL) patients, 25 bilateral incomplete cleft lip (BICL) patients, 39 bilateral complete cleft lip (BCCL) patients. There were 767 patients in the non-prophylactic group, including 482 UICL patients, 211 UCCL patients, 31 BICL patients, 43 BCCL patients. The relationship between preoperative and postoperative leukocyte count, preoperative and postoperative body temperature, and postoperative wound infection were compared between the two groups.
No significant difference was observed in the leukocyte count and body temperature between both groups (>0.05).
The preoperative prophylactic use of antibiotics has no significant effect on the incidence of postoperative infection in patients undergoing cleft lip repair.
研究术前预防性使用抗生素对唇裂患者伤口感染的影响。
对2015年1月至2018年11月在四川大学华西口腔医院唇腭裂科接受一期唇裂修复术的1361例患者的临床资料进行回顾性研究。根据是否使用预防性抗生素将患者分为两组。预防组有594例患者，其中单侧不完全性唇裂（UICL）患者373例、单侧完全性唇裂（UCCL）患者157例、双侧不完全性唇裂（BICL）患者25例、双侧完全性唇裂（BCCL）患者39例。非预防组有767例患者，其中UICL患者482例、UCCL患者211例、BICL患者31例、BCCL患者43例。比较两组术前和术后白细胞计数、术前和术后体温以及术后伤口感染情况。
两组白细胞计数和体温差异无统计学意义（>0.05）。
术前预防性使用抗生素对唇裂修复患者术后感染发生率无显著影响。
