Bykova V P
National Medical Research Center of Otorhinolaryngology of the Federal Biomedical Agency of Russia, Moscow, Russia.
Arkh Patol. 2021;83(6):27-34. doi: 10.17116/patol20218306127.
Along with central immune organs, the peripheral lymphoepithelial organs of the pharynx are actively involved in protecting the body from infections. Adaptive, or induced, immunity occurs during the postnatal ontogenesis of immunocompetent lymphocytes, which includes the secondary somatic recombination of the V genes with the participation of recombination-activating gene (RAG) and terminal deoxynucleotidyl transferase (Tdt) proteins. This publication discusses the results of detection of Tdt-positive cells in the pharyngeal and palatine tonsils of children of different ages, who had been operated on for adenoid vegetations and chronic tonsillitis. Attention is drawn to the localization of Tdt cells, the level of Tdt expression, an attempt to clarify the phenotype, destination, and place in the diagnostic arrays of functional markers when an adaptive immunity is generated in children.
除了中枢免疫器官外，咽部的外周淋巴上皮器官也积极参与保护身体免受感染。适应性免疫或诱导性免疫发生在免疫活性淋巴细胞的出生后个体发育过程中，这包括V基因的二次体细胞重组，该过程有重组激活基因（RAG）和末端脱氧核苷酸转移酶（Tdt）蛋白的参与。本出版物讨论了对不同年龄段因腺样体肥大和慢性扁桃体炎接受手术的儿童的咽扁桃体和腭扁桃体中Tdt阳性细胞的检测结果。文中关注了Tdt细胞的定位、Tdt表达水平，试图阐明儿童产生适应性免疫时其表型、去向以及在功能标志物诊断阵列中的位置。
