昂丹司琼和阿洛司琼的新方法激发了一种用于吲哚合成的通用流动光化学方法。
New approaches to ondansetron and alosetron inspire a versatile, flow photochemical method for indole synthesis.
作者信息
Sun Wei, Raimbach William A T, Elliott Luke D, Booker-Milburn Kevin I, Harrowven David C
机构信息
Chemistry, University of Southampton, Highfield, Southampton, SO17 1BJ, UK.
School of Chemistry, University of Bristol, Cantock's Close, Bristol, BS8 1TS, UK.
出版信息
Chem Commun (Camb). 2022 Jan 4;58(3):383-386. doi: 10.1039/d1cc05700f.
PMID:34860228
Abstract
An oxidative photocyclisation of -arylenaminones to indoles is described, that mirrors the Fischer indole synthesis but uses anilines in place of arylhydrazines. Its value is exemplified with new approaches to the WHO-listed APIs ondansetron and alosetron.
摘要
描述了一种将芳基烯胺酮氧化光环化生成吲哚的反应，该反应类似于费歇尔吲哚合成，但使用苯胺代替芳基肼。以世界卫生组织列出的原料药昂丹司琼和阿洛司琼的新合成方法为例展示了其价值。
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