Departments of Pediatrics and Neonatology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Department of Clinical Pathology, Faculty of Medicine, Suez Canal University, Ismailia, Egypt.
Pediatr Allergy Immunol Pulmonol. 2021 Dec;34(4):141-146. doi: 10.1089/ped.2021.0077. Epub 2021 Dec 2.
Community-acquired pneumonia (CAP) in infants is a major cause of morbidity and mortality, especially in developing countries. Increased salivary C-reactive protein (CRP) levels have been demonstrated in neonatal pneumonia and other diseases. We investigated the applicability of CRP and mean platelet volume (MPV) in the diagnosis and follow-up of CAP in infants. This prospective observational study included 45 infants admitted for CAP. We measured serum and salivary CRP levels via ELISA, while MPV was measured using an automated blood cell counter. Both salivary and serum CRP values were significantly different in the studied population between admission and follow-up ( = 0.001 and < 0.0001, respectively). The same was observed for MPV ( < 0.0001). We found significant positive correlations between serum and salivary CRP ( = 0.652, < 0.0001) and between serum CRP and MPV ( = 0.495, = 0.001), as well as between salivary CRP and MPV ( = 0.439, = 0.003). Receiver operating curve analysis showed that salivary CRP at a cutoff value of 3.2 ng/L had a sensitivity of 97.2% and specificity of 90%, while MPV at a cutoff value of 8.4 fL showed 91% sensitivity and 90% specificity. The present study showed that both salivary CRP and MPV are reliable diagnostic markers of CAP in infants.
社区获得性肺炎（CAP）是婴儿发病和死亡的主要原因，尤其在发展中国家。研究表明，唾液 C 反应蛋白（CRP）水平在新生儿肺炎和其他疾病中升高。我们研究了 CRP 和血小板平均体积（MPV）在婴儿 CAP 诊断和随访中的适用性。这项前瞻性观察性研究纳入了 45 名因 CAP 入院的婴儿。我们通过酶联免疫吸附试验（ELISA）检测血清和唾液 CRP 水平，使用自动血细胞计数器检测 MPV。在入院和随访时，研究人群的唾液和血清 CRP 水平均有显著差异（=0.001 和 < 0.0001），MPV 也是如此（ < 0.0001）。我们发现血清和唾液 CRP 之间存在显著的正相关（=0.652， < 0.0001），血清 CRP 和 MPV 之间也存在显著的正相关（=0.495， = 0.001），唾液 CRP 和 MPV 之间也存在显著的正相关（=0.439， = 0.003）。受试者工作特征曲线分析显示，唾液 CRP 截断值为 3.2ng/L 时，灵敏度为 97.2%，特异性为 90%，MPV 截断值为 8.4fL 时，灵敏度为 91%，特异性为 90%。本研究表明，唾液 CRP 和 MPV 均是婴儿 CAP 的可靠诊断标志物。
