Nĕmec J, Zamrazil V, Pohunkovå D, Röhling S, Zeman V
Endocrinol Exp. 1986 Mar;20(1):85-95.
Two groups of patients with less advanced stages of differentiated thyroid cancer were followed from 2 to more than 25 years: 1. 326 patients with preventive thyroid ablation (PTA) in cases of a tumor without lymphatic and remote metastases; 2. 471 patients with lymph node syndrome. It was found that the survival of patients with lymph node syndrome was less including the group below 40 years of age. Within the first group (with PTA) the survival was less in cases with the invasion of tumor through the thyroid capsula (stage T3 according to WHO classification). In both groups neither any significant effect of sex nor histological characteristics of the tumor (i.e. papillary v.s. follicular) was found. However, the effect of age was found to be remarkable in both groups, the prognosis being worse in patients after 40 years of age. Finally, the prognosis of less advanced stages of differentiated cancer was much better than than in patients with remote metastases.
两组分化型甲状腺癌分期较早期的患者被随访了2至25年以上：1. 326例肿瘤无淋巴和远处转移而行预防性甲状腺切除（PTA）的患者；2. 471例有淋巴结综合征的患者。结果发现，有淋巴结综合征的患者生存率较低，包括40岁以下的患者组。在第一组（行PTA的患者）中，肿瘤侵犯甲状腺被膜（根据WHO分类为T3期）的患者生存率较低。在两组中，均未发现性别及肿瘤组织学特征（即乳头状与滤泡状）有任何显著影响。然而，两组中年龄的影响均显著，40岁以上患者的预后较差。最后，分化型癌较早期阶段的预后远好于有远处转移的患者。
