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Elimination of fluorescent protein immunogenicity permits modeling of metastasis in immune-competent settings.

作者信息

Grzelak Candice A, Goddard Erica T, Lederer Emma E, Rajaram Kamya, Dai Jinxiang, Shor Ryann E, Lim Andrea R, Kim Jeanna, Beronja Slobodan, Funnell Alister P W, Ghajar Cyrus M

机构信息

Public Health Sciences Division and Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

Public Health Sciences Division and Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA.

出版信息

Cancer Cell. 2022 Jan 10;40(1):1-2. doi: 10.1016/j.ccell.2021.11.004. Epub 2021 Dec 2.


DOI:10.1016/j.ccell.2021.11.004
PMID:34861158
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9668376/
Abstract
摘要

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本文引用的文献

[1]
A mouse model that is immunologically tolerant to reporter and modifier proteins.

Commun Biol. 2020-5-29

[2]
Transgenic mice that accept Luciferase- or GFP-expressing syngeneic tumor cells at high efficiencies.

Genes Cells. 2018-7

[3]
Tolerance is established in polyclonal CD4(+) T cells by distinct mechanisms, according to self-peptide expression patterns.

Nat Immunol. 2016-2

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"Glowing head" mice: a genetic tool enabling reliable preclinical image-based evaluation of cancers in immunocompetent allografts.

PLoS One. 2014-11-4

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Gene Ther. 2009-1-8

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Efficient tumour formation by single human melanoma cells.

Nature. 2008-12-4

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Science. 2008-8-8

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Identification of the immunodominant CTL epitope of EGFP in C57BL/6 mice.

Gene Ther. 2008-5

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Immunogenicity of enhanced green fluorescent protein (EGFP) in BALB/c mice: identification of an H2-Kd-restricted CTL epitope.

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Mol Cell Biol. 2000-6

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