Sawada K
Hokkaido Igaku Zasshi. 1986 Jan;61(1):72-82.
CFU-E growth from fractionated bone marrow cells of five patients with Diamond Blackfan syndrome was studied. In all patients, CFU-E growth was reduced in mononuclear cell rich fraction. In two patients out of five, CFU-E growth was returned to normal by the depletion of E-rosette forming cells of monocytes from mononuclear cell rich fraction. In the patient whose CFU-E growth returned to normal by the depletion of E-rosette forming cells, cocultivation between bone marrow buffy coat cells and autologous bone marrow E-rosette forming cells resulted in a significant decrease of CFU-E growth, and there was a significant increase in CFU-E growth by the treatment of OKT 4. In other three patients out of five, there was no significant increase in CFU-E growth by the depletion of monocytes and/or E-rosette forming cells. It is concluded that immunologic causes such as cellular factors may play a role, at least in part, on the pathogenesis of Diamond-Blackfan syndrome.
对五名先天性纯红细胞再生障碍性贫血综合征患者的分级骨髓细胞的集落形成单位-红细胞（CFU-E）生长情况进行了研究。在所有患者中，富含单核细胞的部分中CFU-E生长均降低。五名患者中有两名患者，通过从富含单核细胞的部分中去除单核细胞的E玫瑰花结形成细胞，CFU-E生长恢复正常。在通过去除E玫瑰花结形成细胞使CFU-E生长恢复正常的患者中，骨髓血沉棕黄层细胞与自体骨髓E玫瑰花结形成细胞之间的共培养导致CFU-E生长显著降低，并且通过OKT 4治疗CFU-E生长显著增加。在另外三名患者中，去除单核细胞和/或E玫瑰花结形成细胞后CFU-E生长没有显著增加。得出的结论是，诸如细胞因子等免疫因素可能至少部分地在先天性纯红细胞再生障碍性贫血综合征的发病机制中起作用。
