Wiesner R H
J Clin Gastroenterol. 1986 Feb;8(1):74-6. doi: 10.1097/00004836-198602000-00016.
A 52-year-old woman with primary biliary cirrhosis who had never had hepatic coma developed it while taking propranolol. The coma receded when the propranolol was stopped and 2 days later gastrointestinal bleeding did not precipitate hepatic coma. This raises the question whether propranolol and other beta blockers lead to hepatic encephalopathy.
一名52岁的原发性胆汁性肝硬化女性患者,此前从未发生过肝昏迷,但在服用普萘洛尔期间出现了肝昏迷。停用普萘洛尔后昏迷消退,两天后胃肠道出血并未引发肝昏迷。这就提出了一个问题,即普萘洛尔和其他β受体阻滞剂是否会导致肝性脑病。