From the Bakırkoy Training and Research Hospital for Psychiatry Neurology and Neurosurgery, Research, Treatment and Training Center for Alcohol and Substance Dependence (AMATEM), Istanbul, Turkey (IA); Bakırkoy Training and Research Hospital for Psychiatry Neurology and Neurosurgery, Psychiatry Clinic, Istanbul, Turkey (SU).
J Addict Med. 2022;16(4):492-494. doi: 10.1097/ADM.0000000000000941. Epub 2021 Dec 3.
Bupropion is a widely used antidepressant that plays an essential role in treating mental disorders. Due to its structural similarities with psychostimulants, bupropion is suggested to have addictive potential. Several case reports have been published addressing its misuse in recent years, mainly through nasal insufflation and intravenous administration. Most of the reported cases cited a history of substance use disorder.
Written informed consent was obtained from the patient to write this case report.
We present a case with alcohol use disorder and attention deficit hyperactivity disorder, who developed a substance use disorder to bupropion while chewing it in doses up to 2250 mg, in an attempt to get "high" with no history of seizures.
Our case suggests that bupropion can also be misused by chewing even at high doses and that it can lead to a substance use disorder. Its use in various indications in treating mental disorders and its over-the-counter accessibility, along with a lower risk of stigmatization, could increase the prevalence of bupropion misuse. It is essential to know the medical consequences of bupropion misuse as there is increasing data on its addictive potential. More information is needed to clarify the impact of the route of administration on drug metabolism and adverse effects.
安非他酮是一种广泛使用的抗抑郁药，在治疗精神障碍方面发挥着重要作用。由于其与精神兴奋剂的结构相似，安非他酮被认为具有潜在的成瘾性。近年来，已有几篇病例报告发表，主要涉及通过鼻腔吸入和静脉注射滥用安非他酮的情况。大多数报道的病例都有物质使用障碍史。
已获得患者的书面知情同意，以撰写本病例报告。
我们报告了一个患有酒精使用障碍和注意缺陷多动障碍的病例，该患者在咀嚼安非他酮时，剂量高达 2250 毫克，试图通过“嗑药”获得快感，但没有癫痫发作史，导致出现了物质使用障碍。
我们的病例表明，即使在高剂量下咀嚼安非他酮也可能被滥用，并可能导致物质使用障碍。由于安非他酮在治疗精神障碍的各种适应证中都有应用，且可在柜台购买，加之其滥用带来的污名化风险较低，可能会增加安非他酮滥用的发生率。了解安非他酮滥用的医学后果非常重要，因为越来越多的数据表明它具有成瘾性。需要更多信息来阐明给药途径对药物代谢和不良反应的影响。
