Department of Pulmonary Medicine, Sleep and Critical Care, All India Institute of Medical Sciences, Jodhpur.
Rajasthan Hospital, Jaipur.
Monaldi Arch Chest Dis. 2021 Dec 3;92(3). doi: 10.4081/monaldi.2021.2091.
Blood urea nitrogen and serum albumin levels are independent risk factors for poor clinical outcome in CAP. However, there is a paucity in the literature on the role of Blood urea nitrogen and albumin ratio(B/A) in CAP. This was a prospective observational study in which 112 admitted patients with the diagnosis of CAP underwent routine blood examinations, ABG, procalcitonin and Chest X-ray. Univariate analysis among various risk factors, CURB-65 scores, blood parameters including B/A ratios and clinical outcomes were carried out followed by multiple logistic regression. Cox regression was done to look at B/A values and time to mortality. In the logistic regression, age, CURB -65 score, B/A ratio and procalcitonin came out to be independent risk factors for ICU admission and mortality. Odds ratio of B/A in predicting mortality and ICU admission came out to be 67.8 (49.2-95.4) and 11.2 (8.4-14), respectively. Cox regression showed B/A values were also found to have a statistically significant relationship with time to mortality (p=0.001). B/A ratio has the potential to become a veritable predictor of poor clinical outcomes in patients with CAP.
血尿素氮和血清白蛋白水平是 CAP 不良临床结局的独立危险因素。然而,关于 CAP 中血尿素氮与白蛋白比值(B/A)的作用,文献报道较少。这是一项前瞻性观察研究,共纳入 112 例确诊为 CAP 的住院患者,进行常规血液检查、ABG、降钙素原和胸部 X 线检查。对各种危险因素、CURB-65 评分、血液参数(包括 B/A 比值)和临床结局进行单因素分析,然后进行多因素逻辑回归。Cox 回归分析 B/A 值与死亡率之间的关系。在逻辑回归中,年龄、CURB-65 评分、B/A 比值和降钙素原是 ICU 入住和死亡的独立危险因素。B/A 比值预测死亡率和 ICU 入住的比值比分别为 67.8(49.2-95.4)和 11.2(8.4-14)。Cox 回归显示,B/A 值与死亡率之间也存在统计学显著关系(p=0.001)。B/A 比值有可能成为 CAP 患者不良临床结局的可靠预测指标。