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血尿素氮与血清白蛋白比值在预测社区获得性肺炎(CAP)严重程度中的作用。

Role of blood urea nitrogen and serum albumin ratio in predicting severity of community acquired pneumonia (CAP).

机构信息

Department of Pulmonary Medicine, Sleep and Critical Care, All India Institute of Medical Sciences, Jodhpur.

Rajasthan Hospital, Jaipur.

出版信息

Monaldi Arch Chest Dis. 2021 Dec 3;92(3). doi: 10.4081/monaldi.2021.2091.

Abstract

Blood urea nitrogen and serum albumin levels are independent risk factors for poor clinical outcome in CAP. However, there is a paucity in the literature on the role of Blood urea nitrogen and albumin ratio(B/A) in CAP. This was a prospective observational study in which 112 admitted patients with the diagnosis of CAP underwent routine blood examinations, ABG, procalcitonin and Chest X-ray. Univariate analysis among various risk factors, CURB-65 scores, blood parameters including B/A ratios and clinical outcomes were carried out followed by multiple logistic regression. Cox regression was done to look at B/A values and time to mortality. In the logistic regression, age, CURB -65 score, B/A ratio and procalcitonin came out to be independent risk factors for ICU admission and mortality. Odds ratio of B/A in predicting mortality and ICU admission came out to be 67.8 (49.2-95.4) and 11.2 (8.4-14), respectively. Cox regression showed B/A values were also found to have a statistically significant relationship with time to mortality (p=0.001). B/A ratio has the potential to become a veritable predictor of poor clinical outcomes in patients with CAP.

摘要

血尿素氮和血清白蛋白水平是 CAP 不良临床结局的独立危险因素。然而,关于 CAP 中血尿素氮与白蛋白比值(B/A)的作用,文献报道较少。这是一项前瞻性观察研究,共纳入 112 例确诊为 CAP 的住院患者,进行常规血液检查、ABG、降钙素原和胸部 X 线检查。对各种危险因素、CURB-65 评分、血液参数(包括 B/A 比值)和临床结局进行单因素分析,然后进行多因素逻辑回归。Cox 回归分析 B/A 值与死亡率之间的关系。在逻辑回归中,年龄、CURB-65 评分、B/A 比值和降钙素原是 ICU 入住和死亡的独立危险因素。B/A 比值预测死亡率和 ICU 入住的比值比分别为 67.8(49.2-95.4)和 11.2(8.4-14)。Cox 回归显示,B/A 值与死亡率之间也存在统计学显著关系(p=0.001)。B/A 比值有可能成为 CAP 患者不良临床结局的可靠预测指标。

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