Since everyone has a donor, why are some eligible patients still not transplanted?

Hematopoietic cell transplantation is an important treatment option for malignant and non-malignant hematologic diseases. Despite increasing the potential donor pool for hematopoietic cell transplantation there are many patients who are unable to access this treatment. There are several biologic and non-biologic factors that may explain lower utilization of transplantation. Biologic factors associated with lower utilization include older age, multiple comorbidities, persons of African American descent and high-risk disease that may not respond optimally to hematopoietic cell transplantation. Non-biologic factors associated with lower utilization include lower educational (without a high school diploma) or social status, uninsured, Medicaid or Medicare insurance and in persons aged ≥60 years, when the distance between their residence and hospital was greater than 37 miles. The decision to proceed to hematopoietic cell transplantation is a dialogue between the patient and the treating physician. While some patients may be considered poor candidates for continued treatment including hematopoietic cell transplantation others may be offered novel pharmacologic and cellular therapies with a capacity to deliver specific immunologic antitumor responses. Pharmacologic and cellular therapies are relatively recent, and it is not known whether the biologic and non-biologic factors that limit access to transplantation will limit access to these newer treatments.