Silva Whesley Tanor, Ávila Matheus Ribeiro, de Oliveira Lucas Frois Fernandes, de Souza Iara Nepomuceno, de Almeida Igor Lucas Geraldo Izalino, Madureira Fabrício Pinho, Lacerda Ana Cristina Rodrigues, Mendonça Vanessa Amaral, Pereira Danielle Aparecida Gomes, Lima Vanessa Pereira, Figueiredo Pedro Henrique Scheidt, Costa Henrique Silveira
Departamento de Fisioterapia, Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, Brazil.
Programa de Pós-graduação em Reabilitação e Desempenho Funcional, Universidade Federal dos Vales do Jequitinhonha e Mucuri (UFVJM), Diamantina, Brazil.
J Vasc Nurs. 2021 Dec;39(4):126-133. doi: 10.1016/j.jvn.2021.09.002. Epub 2021 Oct 20.
Chronic venous insufficiency (CVI) has a broad spectrum of clinical expression, ranging from mild to severe cases, which negatively impacts the health-related quality of life (HRQoL). However, the comparison in HRQoL between mild and severe CVI has not yet been systematically discussed, which could assist in the adoption of preventive strategies METHODS: A systematic review and meta-analysis was conducted (protocol register https://osf.io/mr4aj/) following a search of the MEDLINE, CINAHL, Web of Science, LILACS, and Scopus databases, using the terms related to CVI and HRQoL. Observational studies that assessed the HRQoL in individuals with CVI in different degrees of severity were included, without date restriction RESULTS: We retrieved 4750 titles and abstracts and 9 were included in this review. The HRQoL was worse in patients with severe CVI compared to mild patients at Short-form of Health Survey (SF-36) (mean difference 11.02, 95% CI from 8.62 to 13.43; p<0.001), Chronic Venous Insufficiency Quality Of Life Questionnaire (CIVIQ-14) (mean difference 13.07; 95% CI from 11.33 to 14.82; p<0.001) and Aberdeen Varicose Veins Questionnaire (mean difference 7.7; 95% CI: -12.82 to -2.58; p=0.003), especially in the physical domains. There was no difference in the HRQoL between severe and mild patients at CIVIQ-20 (p=0.09) CONCLUSION: The HRQoL was worse in the physical domains in patients with severe CVI when compared to mild patients. However, the heterogeneity of the results was high and the data should be interpreted with caution.
慢性静脉功能不全（CVI）具有广泛的临床症状表现，涵盖从轻度到重度病例，这对健康相关生活质量（HRQoL）产生负面影响。然而，轻度与重度CVI患者在HRQoL方面的比较尚未得到系统探讨，而这种比较有助于采取预防策略。方法：在检索MEDLINE、CINAHL、科学网、拉丁美洲和加勒比地区卫生科学数据库以及Scopus数据库后，按照预先制定的方案（方案注册网址：https://osf.io/mr4aj/）进行了系统评价和荟萃分析，检索词为与CVI和HRQoL相关的术语。纳入评估不同严重程度CVI个体HRQoL的观察性研究，无日期限制。结果：我们检索到4750篇标题和摘要，本综述纳入了9篇。在健康调查简表（SF - 36）方面，重度CVI患者的HRQoL比轻度患者更差（平均差值11.02，95%置信区间为8.62至13.43；p < 0.001），在慢性静脉功能不全生活质量问卷（CIVIQ - 14）方面（平均差值13.07；95%置信区间为11.33至14.82；p < 0.001）以及在阿伯丁静脉曲张问卷方面（平均差值7.7；95%置信区间： - 12.82至 - 2.58；p = 0.003），尤其是在身体领域。在CIVIQ - 20方面，重度和轻度患者的HRQoL没有差异（p = 0.09）。结论：与轻度患者相比，重度CVI患者在身体领域的HRQoL更差。然而，结果的异质性较高，数据解释应谨慎。
