Diabetes Centre of Universidade Federal de São Paulo, Escola Paulista de Medicina, Brazil.
Diabetes Centre of Universidade Federal de São Paulo, Escola Paulista de Medicina, Brazil.
J Diabetes Complications. 2022 Jan;36(1):108082. doi: 10.1016/j.jdiacomp.2021.108082. Epub 2021 Nov 5.
To identify family background characteristics and cardiovascular disease (CVD) risk factors linked to overweight and obesity in Brazilian with type 1 diabetes (T1D).
We performed cross-sectional anthropometric and laboratory analyses in young individuals with T1D.
Among 181 participants, 87 were women and 94 were men (64%/78% normal weight, 27%/15% overweight and 9%/7% obese). Obese men were older; were more likely to be Black; had higher triglyceride levels and diastolic blood pressure (BP), lower estimated glucose disposal rate (eGDR) and higher prevalence of first-degree relatives (FDR) with hypertension and early CVD. Overweight and obese women were more likely to have lower eGDR, and obese women were more likely to have FDR with obesity.
One third of young people with T1D were overweight or obese. Excess weight was associated with family history (FH) of obesity for women and FH of early CVD or hypertension for men. BMI was related to decreased insulin sensitivity in both genders, but only men with T1D had metabolic impairment. Our data highlight the importance of considering family background in individuals with T1D.
确定与超重和肥胖相关的巴西 1 型糖尿病（T1D）患者的家族背景特征和心血管疾病（CVD）危险因素。
我们对年轻的 T1D 患者进行了横断面人体测量和实验室分析。
在 181 名参与者中，87 名女性，94 名男性（64%/78%体重正常，27%/15%超重，9%/7%肥胖）。肥胖男性年龄较大；更有可能是黑人；甘油三酯和舒张压（BP）水平更高，估计葡萄糖处置率（eGDR）更低，一级亲属（FDR）中有高血压和早期 CVD 的比例更高。超重和肥胖的女性更有可能出现较低的 eGDR，而肥胖的女性更有可能有肥胖的 FDR。
三分之一的年轻 T1D 患者超重或肥胖。超重与女性肥胖的家族史（FH）和男性早期 CVD 或高血压的 FH 相关。BMI 与两性的胰岛素敏感性降低有关，但只有 T1D 男性存在代谢异常。我们的数据强调了在 T1D 患者中考虑家族背景的重要性。
