Healthcare-associated Infections in Pediatric Patients in Neurotrauma Intensive Care Unit: A Retrospective Analysis.

BACKGROUND

Healthcare-associated infections (HAIs) can impact the outcome following traumatic brain injury (TBI) in children. We undertook a retrospective observational study to see the incidence, risk factors, and microbiological profile for HAIs in pediatric TBI. We also studied the impact of baseline patient characteristics, HAIs on patient outcome, and antibiotic resistance of different types of bacteria.

MATERIALS AND METHODS

Data on pediatric TBI patients of age up to 12 years were collected via a computerized patient record system (CPRS) from January 2012 to December 2018. Descriptive Chi-square test and Wilcoxon signed rank test were used to characterize baseline parameters. General linear regression models were run to find an unadjusted and adjusted odds ratio (OR).

RESULTS

HAIs were found in 144 (34%) out of 423 patients. The most commonly seen infections were of the respiratory tract in 73 (17.26%) subjects. The most predominant microorganism isolated was in 188 (41%) samples. . was sensitive to colistin in 91 (48.4%) patients. Male gender (OR 0.630; -value 0.035), fall from height (OR 0.374; -value 0.008), and higher injury severity scale (ISS) (OR 1.040; -value 0.002) were independent risk factors for development of HAIs. Severe TBI, higher ISS and Marshall grade, and HAIs were significantly associated with poor patient outcome.

CONCLUSION

Severe TBI poses a significant risk of HAIs. The most common site was the respiratory tract, predominately infected with . HAIs in pediatric TBI patients resulted in poor patient outcome.

HOW TO CITE THIS ARTICLE

Prasad C, Bindra A, Singh P, Singh GP, Singh PK, Mathur P. Healthcare-associated Infections in Pediatric Patients in Neurotrauma Intensive Care Unit: A Retrospective Analysis. Indian J Crit Care Med 2021;25(11):1308-1313.