Bitsika Vicki, Sharpley Christopher F, McMillan Mary E, Jesulola Emmanuel, Agnew Linda L
Brain-Behaviour Research Group, University of New England, Armidale, NSW, Australia.
Belmont Hospital, Belmont, NSW, Australia.
Front Psychiatry. 2021 Nov 18;12:533722. doi: 10.3389/fpsyt.2021.533722. eCollection 2021.
In order to evaluate the effects of specific forms of childhood maltreatment (CM) upon adult C-reactive protein (CRP) concentrations, and to further describe the potentially confounding role that recent life stress and depression hold in that relationship, 221 participants from rural Australia ( age = 44yr, SD = 17.8yr) completed self-report questionnaires and provided a blood sample. There were no sex differences in any variables across the 91 males and 130 females, but depression status did confound the association between global CM and CRP. The specific aspect of CM was identified as physical and mental health abuse, and this was significantly associated with CRP level in participants with depressive symptoms and those without. There was no significant confound from recent life stressors. Results hold implications for the diagnosis of CM-related CRP elevation and (potentially) depression.
为了评估特定形式的童年虐待（CM）对成人C反应蛋白（CRP）浓度的影响，并进一步描述近期生活压力和抑郁在这种关系中可能存在的混杂作用，来自澳大利亚农村的221名参与者（年龄=44岁，标准差=17.8岁）完成了自我报告问卷并提供了血样。91名男性和130名女性在任何变量上均无性别差异，但抑郁状态确实混淆了总体童年虐待与CRP之间的关联。童年虐待的具体方面被确定为身心健康虐待，这与有抑郁症状和无抑郁症状参与者的CRP水平均显著相关。近期生活压力源没有显著的混杂作用。研究结果对与童年虐待相关的CRP升高以及（可能的）抑郁症的诊断具有启示意义。
