帕金森病患者及其照料者的认知影响：来自澳大利亚队列的观点
Cognitive Influences in Parkinson's Disease Patients and Their Caregivers: Perspectives From an Australian Cohort.
作者信息
Lubomski Michal, Davis Ryan L, Sue Carolyn M
机构信息
Department of Neurology, Royal North Shore Hospital, Northern Sydney Local Health District, St Leonards, NSW, Australia.
Department of Neurogenetics, Kolling Institute, Faculty of Medicine and Health, University of Sydney, Northern Sydney Local Health District, St Leonards, NSW, Australia.
出版信息
Front Neurol. 2021 Nov 15;12:673816. doi: 10.3389/fneur.2021.673816. eCollection 2021.
Cognitive impairment impacts negatively on Parkinson's disease (PD) patient and caregiver quality of life (QoL). We examined cognitive impairment in PD patients and their caregivers to determine if caregiver cognition affected their PD relative. Validated cognition and clinical outcome measures were assessed in 103 PD patients and 81 caregivers. PD patients showed more cognitive impairment than their carers, with 48.6% having possible Mild Cognitive Impairment (MCI) and 16.5% having PD dementia. Increasing age, male gender, lower education level, various non-motor symptoms and certain therapies, associated with poorer cognition in PD. Eighteen and a half percent of caregivers were found to have MCI, in association with a lower physical and mental QoL. This reflected in lower QoL and mood for the respective PD patients. Impaired cognition and QoL in caregivers was associated with decreased QoL and mood for respective PD patients, suggesting MCI in caregivers is an important consideration for the management of PD.
认知障碍对帕金森病（PD）患者及其照料者的生活质量（QoL）产生负面影响。我们对PD患者及其照料者的认知障碍进行了研究，以确定照料者的认知是否会影响其患PD的亲属。对103名PD患者和81名照料者进行了经过验证的认知和临床结局评估。PD患者比其照料者表现出更多的认知障碍，48.6%的患者可能患有轻度认知障碍（MCI），16.5%的患者患有PD痴呆。年龄增长、男性、教育水平较低、各种非运动症状以及某些治疗方法与PD患者较差的认知相关。发现18.5%的照料者患有MCI，这与较低的身心健康QoL相关。这反映在相应PD患者较低的QoL和情绪上。照料者的认知障碍和QoL与相应PD患者的QoL和情绪下降相关，表明照料者的MCI是PD管理中的一个重要考虑因素。
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