Li He, Zhang Chen, Ji Yong
Tianjin Key Laboratory of Cerebrovascular and of Neurodegenerative Diseases, Department of Neurology, Tianjin Huanhu Hospital, Tianjin, China.
Tianjin Key Laboratory of Cerebrovascular and of Neurodegenerative Diseases, Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin, China.
Front Genet. 2021 Nov 18;12:777942. doi: 10.3389/fgene.2021.777942. eCollection 2021.
The susceptibility of the rs1564282 variant in Parkinson's disease (PD) in Europeans was identified using a series of published genome-wide association studies. Recently, some studies focused on the association between rs1564282 and PD risk in Chinese populations but with inconsistent results. Thus, we conducted an updated meta-analysis with a total of 7,881 samples (4,055 PD cases and 3,826 controls) from eligible studies. After excluding significant heterogeneity, we showed that the rs1564282 variant was significantly associated with PD in Chinese populations ( = 1.00E-04, odds ratio = 1.28 and 95% confidence interval = 1.16-1.42). The sensitivity analysis showed that the association between rs1564282 and PD was not greatly influenced, and there was no significant publication bias among the included studies. Consequently, this meta-analysis indicates that the rs1564282 variant is significantly associated with susceptibility to PD in Chinese populations.
通过一系列已发表的全基因组关联研究，确定了欧洲人群中帕金森病（PD）的rs1564282变异的易感性。最近，一些研究聚焦于rs1564282与中国人群PD风险之间的关联，但结果不一致。因此，我们对符合条件的研究中的总共7881个样本（4055例PD病例和3826例对照）进行了更新的荟萃分析。在排除显著异质性后，我们发现rs1564282变异与中国人群的PD显著相关（P = 1.00E - 04，比值比 = 1.28，95%置信区间 = 1.16 - 1.42）。敏感性分析表明，rs1564282与PD之间的关联未受到很大影响，纳入的研究之间也没有显著的发表偏倚。因此，这项荟萃分析表明rs1564282变异与中国人群对PD的易感性显著相关。
