Persson U, Eklund A
Int Arch Allergy Appl Immunol. 1986;80(2):185-91. doi: 10.1159/000234050.
Attempts have been made to activate alveolar cells obtained by bronchoalveolar lavage from 17 patients with sarcoidosis in different stages with the lectins concanavalin A and leukoagglutinin. The cells obtained from 2 of the patients responded well by proliferation whereas the cells from the other 15 patients responded poorly. Coculture experiments indicate that the low proliferative response was not due to inhibitory effects exerted by alveolar lymphocytes or macrophages, but rather to a lack of responding T cells. The results are discussed in relation to other studies showing increased immune reactivity in alveolar lymphocytes from patients with sarcoidosis.
研究人员尝试用伴刀豆球蛋白A和白细胞凝集素激活从17例处于不同阶段的结节病患者支气管肺泡灌洗获得的肺泡细胞。从2例患者获得的细胞通过增殖反应良好，而从其他15例患者获得的细胞反应较差。共培养实验表明，低增殖反应不是由于肺泡淋巴细胞或巨噬细胞施加的抑制作用，而是由于反应性T细胞的缺乏。结合其他显示结节病患者肺泡淋巴细胞免疫反应性增加的研究对结果进行了讨论。
