Miller K, Scott M P, Hutchinson A P, Nicklin S
Int J Immunopharmacol. 1986;8(2):237-41. doi: 10.1016/0192-0561(86)90064-0.
Oral administration of dioctyltin dichloride (DOTC) results in the production or release of factors which appear to prevent thymocyte maturation at an early stage. Sera obtained from rats gavaged with 75 mg DOTC/kg on alternate days, significantly inhibited PHA-induced blastogenesis of normal thymocytes. In vitro uptake of tritiated thymidine by thymocytes obtained from DOTC-gavaged rats was markedly reduced. These events occurred 24 to 72 h after commencement of DOTC treatment and preceded overt thymic weight loss. The effects of DOTC may therefore be a consequence of factor(s) capable of blocking the intrathymic differentiation of T cell precursors.
口服二氯化二辛基锡（DOTC）会导致某些因子的产生或释放，这些因子似乎在早期阶段就能阻止胸腺细胞的成熟。每隔一天用75毫克DOTC/千克灌胃的大鼠所获得的血清，能显著抑制正常胸腺细胞由PHA诱导的母细胞生成。从接受DOTC灌胃的大鼠获取的胸腺细胞对氚标记胸腺嘧啶核苷的体外摄取明显减少。这些情况发生在DOTC治疗开始后的24至72小时，且早于胸腺重量明显减轻之前。因此，DOTC的作用可能是由能够阻断T细胞前体胸腺内分化的某种因子所导致的结果。
