Fakhouri Eddie W, Weingarten Jeremy A, Singh Shailendra P, Shah Purvi, Peterson Stephen J
New York-Presbyterian Brooklyn Methodist Hospital, Brooklyn, NY 11215, USA.
Department of Medicine, Weill Cornell Medicine, New York, NY 10065, USA.
Oxid Med Cell Longev. 2021 Nov 24;2021:7138800. doi: 10.1155/2021/7138800. eCollection 2021.
Obstructive sleep apnea (OSA) is a sleep disorder characterized by intermittent hypoxia, chronic inflammation, and oxidative stress and is associated with cardiometabolic disease. Several biological substrates have been associated with OSA such as nephroblastoma overexpressed (NOV), endothelial progenitor cells (EPC), and circulating endothelial cells (CEC). Few studies have looked at the association of NOV with OSA while the EPC/CEC relationships with OSA are unclear. In this study, we hypothesize that (1) NOV is associated with the severity of OSA independent of BMI, identifying a protein that may play a role in the biogenesis of OSA complications, and (2) EPCs and CECs are also associated with the severity of OSA and are biomarkers of endothelial dysfunction in OSA.
61 subjects underwent overnight polysomnography (PSG), clinical evaluation, and blood analysis for NOV, EPC, CEC, interleukin 6 (IL-6), and other potential biomarkers.
NOV and EPCs were independently associated with the oxygen desaturation index (ODI) after adjusting for potential confounders including body mass index (BMI), age, and sex (NOV = 0.032; EPC = 0.001). EPC was also independently associated with AHI after adjusting for BMI, age, and sex ( = 0.017). IL-6 was independently associated with AHI, but not with ODI.
NOV and EPC levels correlate with the degree of OSA independent of BMI, indicating that these biomarkers could potentially further elucidate the relationship between OSA patients and their risk of the subsequent development of cardiovascular disease.
阻塞性睡眠呼吸暂停（OSA）是一种以间歇性缺氧、慢性炎症和氧化应激为特征的睡眠障碍，与心脏代谢疾病有关。几种生物底物已被证实与OSA有关，如过表达的肾母细胞瘤（NOV）、内皮祖细胞（EPC）和循环内皮细胞（CEC）。很少有研究探讨NOV与OSA的关系，而EPC/CEC与OSA的关系尚不清楚。在本研究中，我们假设：（1）NOV与OSA的严重程度相关，且独立于BMI，确定一种可能在OSA并发症生物发生中起作用的蛋白质；（2）EPC和CEC也与OSA的严重程度相关，并且是OSA内皮功能障碍的生物标志物。
61名受试者接受了整夜多导睡眠图（PSG）检查、临床评估以及对NOV、EPC、CEC、白细胞介素6（IL-6）和其他潜在生物标志物的血液分析。
在调整包括体重指数（BMI）、年龄和性别等潜在混杂因素后，NOV和EPC与氧去饱和指数（ODI）独立相关（NOV = 0.032；EPC = 0.001）。在调整BMI、年龄和性别后，EPC也与呼吸暂停低通气指数（AHI）独立相关（= 0.017）。IL-6与AHI独立相关，但与ODI无关。
NOV和EPC水平与OSA的严重程度相关，且独立于BMI，表明这些生物标志物可能进一步阐明OSA患者与其后续发生心血管疾病风险之间的关系。
