Breiter N, Kneschaurek P, Burger G, Huczkowski J, Trott K R
Int J Radiat Biol Relat Stud Phys Chem Med. 1986 Jun;49(6):1031-8. doi: 10.1080/09553008514553251.
Late damage in the rectum of rats was studied after local irradiation with 2 MeV fast fission neutrons and the results were compared with those for 300 kV X-rays. A similarity between latency times, and between clinical, gross pathological and histological appearances of the rectal obstruction after the two types of radiation was observed. The r.b.e. evaluated from ED 50/200 days values was 1.8 for single doses, 2.1 for two fractions and 3 for five fractions and these are similar to r.b.e.s from other investigations of chronic intestinal radiation damage. Using linear quadratic analysis, a limiting r.b.e. of 5 was obtained. The beta-values are similar for both radiation qualities. Because of the high gamma-contamination (25 per cent) in the RENT I beam a possible correction of the r.b.e. for neutrons only, assuming interaction, is discussed.
研究了大鼠直肠局部接受2兆电子伏快裂变中子照射后的晚期损伤，并将结果与300千伏X射线照射的结果进行了比较。观察到两种辐射后直肠梗阻的潜伏期以及临床、大体病理和组织学表现之间的相似性。根据ED 50/200天的值评估的相对生物效应，单剂量时为1.8，分两次照射时为2.1，分五次照射时为3，这些与其他慢性肠道辐射损伤研究中的相对生物效应相似。使用线性二次分析，得到的极限相对生物效应为5。两种辐射质的β值相似。由于RENT I束中存在高γ污染（25%），讨论了仅假设相互作用时对中子相对生物效应进行可能校正的问题。
