局灶性脑缺血中局部脑血流量、局部脑血容量和血脑屏障的序贯评估：病例报告

Sequential assessment of regional cerebral blood flow, regional cerebral blood volume, and blood-brain barrier in focal cerebral ischemia: a case report.

作者信息

Di Piero V, Perani D, Savi A, Gerundini P, Lenzi G L, Fazio F

出版信息

J Cereb Blood Flow Metab. 1986 Jun;6(3):379-84. doi: 10.1038/jcbfm.1986.62.

DOI:10.1038/jcbfm.1986.62

Abstract

Regional CBF (rCBF) and regional cerebral blood volume (rCBV) were evaluated by N,N,N'-trimethyl-N'-(2)-hydroxy-3-methyl-5-[123I]iodobenzyl-1, 3-propanediamine-2 HCl- and 99mTC-labeled red blood cells, respectively, and single-photon emission computerized tomography (SPECT) in a patient with focal cerebral ischemia. Sequential transmission computerized tomography (TCT) and SPECT functional data were compared with clinical findings to monitor the pathophysiological events occurring in stroke. A lack of correlation between rCBF-rCBV distributions and blood-brain barrier (BBB) breakdown was found in the acute phase. In the face of more prolonged alteration of BBB, as seen by TCT enhancement, a rapid evolution of transient phenomena such as luxury perfusion was shown by SPECT studies. Follow-up of the patient demonstrated a correlation between the neurological recovery and a parallel relative improvement of the cerebral perfusion.

摘要

通过使用 N,N,N'-三甲基-N'-(2)-羟基-3-甲基-5-[123I]碘苄基-1,3-丙二胺二盐酸盐和 99mTC 标记的红细胞，分别对一名局灶性脑缺血患者进行单光子发射计算机断层扫描（SPECT），评估局部脑血流量（rCBF）和局部脑血容量（rCBV）。将序贯传输计算机断层扫描（TCT）和 SPECT 功能数据与临床发现进行比较，以监测中风时发生的病理生理事件。在急性期，发现 rCBF-rCBV 分布与血脑屏障（BBB）破坏之间缺乏相关性。通过 TCT 增强可见，在 BBB 发生更持久改变的情况下，SPECT 研究显示出诸如过度灌注等短暂现象的快速演变。对该患者的随访表明，神经功能恢复与脑灌注的平行相对改善之间存在相关性。