Taksande Amar, Pujari Divya, Jameel Patel Zeeshan, Taksande Bharati, Meshram Revat
Department of Pediatrics, Jawaharlal Nehru Medical College, Wardha 442004, Maharashtra, India.
Department of Medicine, Mahatma Gandhi Institute of Medical Sciences, Wardha 442102, Maharashtra, India.
World J Clin Pediatr. 2021 Nov 9;10(6):177-191. doi: 10.5409/wjcp.v10.i6.177.
Pulmonary hypertension (PH) has serious short- and long-term consequences. PH is gaining increasing importance in high risk groups such as Down syndrome (DS) as it influences their overall survival and prognosis. Hence, there is a dire need to collate the prevalence rates of PH in order to undertake definitive measures for early diagnosis and management.
To determine the prevalence of PH in children with DS.
The authors individually conducted a search of electronic databases manually (Cochrane library, PubMed, EMBASE, Scopus, Web of Science). Data extraction and quality control were independently performed by two reviewers and a third reviewer resolved any conflicts of opinion. The words used in the literature search were "pulmonary hypertension" and "pulmonary arterial hypertension"; "Down syndrome" and "trisomy 21" and "prevalence". The data were analyzed by Comprehensive Meta-Analysis Software Version 2. Risk of bias assessment and STROBE checklist were used for quality assessment.
Of 1578 articles identified, 17 were selected for final analysis. The pooled prevalence of PH in these studies was 25.5%. Subgroup analysis was carried out for age, gender, region, year of publication, risk of bias and etiology of PH.
This review highlights the increasing prevalence of PH in children with DS. It is crucial for pediatricians to be aware of this morbid disease and channel their efforts towards earlier diagnosis and successful management. Community-based studies with a larger sample size of children with DS should be carried out to better characterize the epidemiology and underlying etiology of PH in DS.
肺动脉高压（PH）具有严重的短期和长期后果。在唐氏综合征（DS）等高风险群体中，PH的重要性日益凸显，因为它会影响这些群体的总体生存和预后。因此，迫切需要整理PH的患病率，以便采取明确措施进行早期诊断和管理。
确定DS患儿中PH的患病率。
作者手动独立检索电子数据库（Cochrane图书馆、PubMed、EMBASE、Scopus、科学网）。由两名审阅者独立进行数据提取和质量控制，第三名审阅者解决任何意见冲突。文献检索中使用的词汇为“肺动脉高压”和“动脉性肺动脉高压”；“唐氏综合征”、“21三体综合征”和“患病率”。使用综合Meta分析软件版本2对数据进行分析。采用偏倚风险评估和STROBE清单进行质量评估。
在识别出的1578篇文章中，17篇被选入最终分析。这些研究中PH的合并患病率为25.5%。对年龄、性别、地区、发表年份、偏倚风险和PH病因进行了亚组分析。
本综述强调了DS患儿中PH患病率的上升。儿科医生了解这种疾病至关重要，应努力实现早期诊断和成功管理。应开展基于社区的、样本量更大的DS患儿研究，以更好地描述DS中PH的流行病学和潜在病因。
