School of Public Health and Management, Guangzhou University of Chinese Medicine, Guangzhou, China.
Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou, China.
Front Public Health. 2021 Nov 18;9:758335. doi: 10.3389/fpubh.2021.758335. eCollection 2021.
China continues to rank among one of the countries with the highest number of tuberculosis (TB) cases globally. Migrants are a particularly at-risk subgroup for TB and pose a challenge for case management in contemporary China. The early diagnosis and treatment of patients with TB are pivotal for effective TB control. This study investigates the delay in the TB diagnosis of migrants as compared with residents, to provide an evidence base for improved case detection and the better management of migrant patients with TB. The data was collected from the Tuberculosis Information Management System (TBIMS) (2015-2019) in an eastern county of China. The total diagnostic delay, consisting of patient delay and health system delay, is defined as the interval between the onset of TB symptoms and the confirmation of TB diagnosis in the designated TB hospital. The comparison of the delay in the TB diagnosis between migrants and residents was conducted using a Mann-Whitney -test and chi-square test. The difference in the delay curves between these two groups was examined using a log-rank test. Of 2,487 patients with TB, 539 (22%) were migrants. The migrants tended to be younger, presented with less severe conditions, received an initial diagnosis at prefectural and above-level hospitals. Compared with the local patients with TB, the migrant patients with TB had a longer median total diagnostic delay (30 vs. 9, = 0.000) and a higher proportion of patients with this delay >28 days (52 vs. 13%, = 0.000). Similarly, the migrant patients with TB also had a longer median patient delay (13 vs. 9, = 0.000) and a higher proportion of patients with this delay >14 days (47 vs. 30%, = 0.000), longer median health system delay (9 vs. 0, = 0.000), and a higher proportion of patients with this delay >14 days (42 vs. 0.5%, = 0.000) than the local patients with TB. The survival curves of delay showed that the longer the time interval was, the more likely the migrant patients with TB were to be diagnosed ( < 0.05). Diagnosis is significantly delayed among migrant patients with TB. Our study highlights the importance of early screening and diagnosis for TB especially among migrants, to improve access and ensure better management for all patients with TB.
中国仍是全球结核病(TB)病例最多的国家之一。移民是结核病高危亚群,给当代中国的病例管理带来挑战。早期诊断和治疗结核病患者对于有效控制结核病至关重要。本研究旨在调查移民与本地居民之间结核病诊断延迟的差异,为提高病例检出率和改善移民结核病患者管理提供依据。该研究数据来自中国东部某县的结核病信息管理系统(TBIMS)(2015-2019 年)。总诊断延迟包括患者延迟和卫生系统延迟,定义为结核病症状出现到指定结核病医院确诊之间的时间间隔。采用曼-惠特尼 U 检验和卡方检验比较移民和本地居民的诊断延迟差异,对数秩检验比较两组延迟曲线差异。2487 例结核病患者中,539 例(22%)为移民。移民患者年龄较小,病情较轻,初次诊断在县级以上医院进行。与本地结核病患者相比,移民结核病患者的总诊断延迟中位数更长(30 天 vs. 9 天, = 0.000),且延迟>28 天的患者比例更高(52% vs. 13%, = 0.000)。同样,移民结核病患者的患者延迟中位数也更长(13 天 vs. 9 天, = 0.000),且延迟>14 天的患者比例更高(47% vs. 30%, = 0.000),卫生系统延迟中位数也更长(9 天 vs. 0 天, = 0.000),且延迟>14 天的患者比例更高(42% vs. 0.5%, = 0.000)。延迟生存曲线表明,时间间隔越长,移民结核病患者越有可能被诊断( < 0.05)。移民结核病患者的诊断明显延迟。本研究强调了早期筛查和诊断结核病的重要性,特别是对移民而言,以改善所有结核病患者的可及性并确保更好的管理。