Feng Bei, Chen Maojia, Jiang Yanghongyan, Hui Yongfeng, Zhao Qian
Department of Nuclear Medicine, General Hospital of Ningxia Medical University, Yinchuan, China.
West China Hospital of Sichuan University, Chengdu, China.
Front Med (Lausanne). 2021 Nov 12;8:733553. doi: 10.3389/fmed.2021.733553. eCollection 2021.
Bone metastasis of malignant pheochromocytoma is a rare disease. We report a patient with a 10-year history who underwent 18F-FDG PET/CT to detect bone metastasis and receive radiotherapy and chemotherapy with complete response for bilateral iliac pain. A 48-year-old male patient complained of dizziness, hypertension, and bilateral iliac pain for 2 months. The patient had a history of resection of bilateral malignant adrenal pheochromocytoma 10 years earlier, and all complaints were relieved immediately after operation. 18F-FDGPET/CT showed abdominal lymph node uptake and multiple bone uptake, as well as multiple brown fat uptake. A biopsy of the left ilium confirms the metastasis of malignant pheochromocytoma. In our literature review, we discuss the metastasis of pheochromocytoma reported by some scholars, and the role of radionuclides such as 18F-FDG PET/CT, 18F-DOPA PET/CT, I-123MIBG, and 68Ga-DOTATATE PET, in the diagnosis of malignant pheochromocytoma. The patient above is a good case for clinicians in the diagnosis and treatment of metastatic pheochromocytoma, especially in some hospitals with only 18F-FDG imaging agents. A review of this case and similar rare cases in the literature illustrates the importance of 18F-FDG PET/CT in the diagnosis of malignant pheochromocytoma.
恶性嗜铬细胞瘤骨转移是一种罕见疾病。我们报告一例有10年病史的患者，该患者接受了18F-FDG PET/CT检查以检测骨转移，并接受了放疗和化疗，双侧髂骨疼痛完全缓解。一名48岁男性患者抱怨头晕、高血压和双侧髂骨疼痛2个月。该患者10年前有双侧恶性肾上腺嗜铬细胞瘤切除术病史，术后所有症状立即缓解。18F-FDG PET/CT显示腹部淋巴结摄取及多处骨骼摄取，还有多处棕色脂肪摄取。左髂骨活检证实为恶性嗜铬细胞瘤转移。在我们的文献综述中，我们讨论了一些学者报道的嗜铬细胞瘤转移情况，以及18F-FDG PET/CT、18F-DOPA PET/CT、I-123MIBG和68Ga-DOTATATE PET等放射性核素在恶性嗜铬细胞瘤诊断中的作用。上述患者是临床医生诊断和治疗转移性嗜铬细胞瘤的一个很好的病例，尤其是在一些仅有18F-FDG成像剂的医院。对该病例及文献中类似罕见病例的回顾说明了18F-FDG PET/CT在恶性嗜铬细胞瘤诊断中的重要性。
