Cohen M B, Graham L S, Lake R, Metter E J, Fitten J, Kulkarni M K, Sevrin R, Yamada L, Chang C C, Woodruff N
J Nucl Med. 1986 Jun;27(6):769-74.
Tomographic imaging of the brain was performed using a rotating slant hole collimator and [123I]N-isopropyl p-iodoamphetamine (IMP) in normal subjects (n = 6) and patients with either Alzheimer's disease (n = 5) or multiple infarct dementia (n = 3). Four blinded observers were asked to make a diagnosis from the images. Normal subjects and patients with multiple infarct dementia were correctly identified. Alzheimer's disease was diagnosed in three of the five patients with this disease. One patient with early Alzheimer's disease was classified as normal by two of the four observers. Another patient with Alzheimer's disease had an asymmetric distribution of IMP and was incorrectly diagnosed as multiple infarct dementia by all four observers. Limited angle tomography of the cerebral distribution of 123I appears to be a useful technique for the evaluation of demented patients.
在正常受试者（n = 6）以及患有阿尔茨海默病（n = 5）或多发性梗死性痴呆（n = 3）的患者中，使用旋转斜孔准直器和[123I]N-异丙基对碘安非他明（IMP）对大脑进行断层成像。要求四名不知情的观察者根据图像做出诊断。正常受试者和患有多发性梗死性痴呆的患者被正确识别。五名患有阿尔茨海默病的患者中有三名被诊断为此病。四名观察者中有两名将一名早期阿尔茨海默病患者归类为正常。另一名患有阿尔茨海默病的患者IMP分布不对称，所有四名观察者均将其错误诊断为多发性梗死性痴呆。123I脑部分布的有限角度断层成像似乎是评估痴呆患者的一种有用技术。
