Yamamoto Tetsuya, Tsutsumi Kazuya
Department of Chemical Systems Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya-shi 464-8603, Japan.
Department of Materials and Design Innovation Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya-shi 464-8603, Japan.
ACS Omega. 2021 Nov 17;6(47):31677-31682. doi: 10.1021/acsomega.1c04197. eCollection 2021 Nov 30.
Nanovoids contained in hollow particles render them potential drug carriers. However, conventional methods for the synthesis of these particlhes involve complex processes. In this study, we developed a template-free method for the synthesis of hollow polymer and silica particles by initially preparing polystyrene core particles containing 2,2'-azobis(2-methylbutyronitrile) (V-59) through soap-free emulsion polymerization. The subsequent generation of nitrogen gas inside these particles upon the decomposition of V-59 at 70 °C led to the formation of voids. In addition, silica shells were synthesized on the surfaces of the V-59-containing polystyrene core particles through a sol-gel reaction at 40 °C, following which voids were formed by the decomposition of V-59 at 70 °C. The developed method involves straightforward steps and is environmentally friendly, as it does not require the use of surfactants, organic solvents, or templates.
中空颗粒中含有的纳米空隙使其成为潜在的药物载体。然而，合成这些颗粒的传统方法涉及复杂的过程。在本研究中，我们开发了一种无模板方法来合成中空聚合物和二氧化硅颗粒，首先通过无皂乳液聚合制备含有2,2'-偶氮二(2-甲基丁腈)(V-59)的聚苯乙烯核颗粒。随后，在70°C下V-59分解时，这些颗粒内部产生氮气，导致空隙形成。此外，通过在40°C下的溶胶-凝胶反应，在含V-59的聚苯乙烯核颗粒表面合成二氧化硅壳，然后在70°C下V-59分解形成空隙。所开发的方法步骤简单且环保，因为它不需要使用表面活性剂、有机溶剂或模板。
