Kadlec O, Masek K, Zídek Z
Methods Find Exp Clin Pharmacol. 1986 Feb;8(2):127-9.
Serotoninergic contractions of the rat stomach strip were evoked and EC50 determined. In preparations from control animals MDP, 50 mumol/l, decreased EC50 or sensitized the preparation. In the strips from animals where adjuvant arthritis was induced, higher sensitivity to 5-HT was observed and the sensitizing effect of MDP was retained. In the strips from animals pretreated with cyclophosphamide or in the terminal stage of tumor growth lower sensitivity to 5-HT, which could be further decreased by MDP, were noticed. These opposite effects in serotoninergic reactions were tentatively linked with the modulation of the immune status in vivo.
诱发大鼠胃条的血清素能收缩并测定其半数有效浓度（EC50）。在对照动物的制剂中，50μmol/L的甲酰吗啉（MDP）降低了EC50或使制剂敏感。在诱导佐剂性关节炎的动物的胃条中，观察到对5-羟色胺（5-HT）的敏感性更高，并且MDP的致敏作用得以保留。在用环磷酰胺预处理的动物的胃条中或在肿瘤生长末期，注意到对5-HT的敏感性较低，而MDP可使其进一步降低。血清素能反应中的这些相反作用初步与体内免疫状态的调节有关。
