Gallo-Villegas Jaime, Restrepo Daniel, Pérez Laura, Castro-Valencia Leonardo A, Narvaez-Sanchez Raúl, Osorio Jorge, Aguirre-Acevedo Daniel C, Calderón Juan C
From the GRINMADE Group.
Physiology and Biochemistry Research Group-PHYSIS, University of Antioquia.
J Patient Saf. 2022 Jun 1;18(4):295-301. doi: 10.1097/PTS.0000000000000922. Epub 2021 Sep 20.
The aim of the study was to evaluate the safety of high-intensity, low-volume interval training (HIIT-low volume) compared with moderate-intensity continuous aerobic training (MICT) in adults with metabolic syndrome.
This is a controlled, randomized, clinical trial in patients without history of ischemic heart disease or diabetes, who underwent a supervised, 3 sessions/week, 12-week treadmill exercise program. The HIIT-low volume (n = 29) sessions consisted of 6 intervals with 1-minute, high-intensity phases at 90% of peak oxygen consumption (VO2peak). The MICT (n = 31) trained at 60% of VO2peak for 30 minutes. A new approach to record and classify all clinical events according to possible causality based on Naranjo's algorithm was developed.
Patients were 50.8 ± 6.0 years old, 70% women, with body mass index of 30.6 ± 4.0 kg/m2 and VO2peak of 29.0 ± 6.3 mL·kg-1·min-1. In total, 60 clinical events were recorded in the HIIT-low volume group and 48 in the MICT group, with 59.3% classified as general disease. Only 21 events were classified as adverse reactions possibly related to exercise, without any serious adverse reactions. Both interventions had a similar incidence of musculoskeletal events (incidence rate ratio, 1.1; 95% confidence interval, 0.6-1.8), but HIIT-low volume had a higher incidence of cardiovascular events (incidence rate ratio, 2.9; 95% CI, 0.4-22.8) after adjusting for age, sex, and body mass index (HIIT-low volume: chest pain [n = 1] and symptoms of venous insufficiency of lower limbs [n = 2]; MICT: chest pain [n = 1]).
The HIIT-low volume and MICT are safe in patients with metabolic syndrome. We recommend a muscle-conditioning program prior to both and to avoid HIIT-low volume in treadmill in patients with venous insufficiency of the lower limbs.Trial registration number NCT03087721.
本研究旨在评估高强度、低容量间歇训练（HIIT-低容量）与中等强度持续有氧运动训练（MICT）相比，对患有代谢综合征的成年人的安全性。
这是一项针对无缺血性心脏病或糖尿病病史患者的对照、随机临床试验，患者接受每周3次、为期12周的有监督的跑步机运动计划。HIIT-低容量组（n = 29）的训练包括6个间歇，每个间歇有1分钟的高强度阶段，强度为峰值耗氧量（VO2peak）的90%。MICT组（n = 31）以VO2peak的60%进行30分钟训练。开发了一种基于纳兰霍算法根据可能的因果关系记录和分类所有临床事件的新方法。
患者年龄为50.8±6.0岁，70%为女性，体重指数为30.6±4.0kg/m2，VO2peak为29.0±6.3mL·kg-1·min-1。HIIT-低容量组共记录60例临床事件，MICT组记录48例，其中59.3%归类为一般疾病。仅21例事件归类为可能与运动相关的不良反应，无任何严重不良反应。调整年龄、性别和体重指数后，两种干预措施的肌肉骨骼事件发生率相似（发生率比，1.1；95%置信区间，0.6 - 1.8），但HIIT-低容量组心血管事件发生率较高（发生率比，2.9；95%CI，0.4 - 22.8）（HIIT-低容量组：胸痛[n = 1]和下肢静脉功能不全症状[n = 2]；MICT组：胸痛[n = 1]）。
HIIT-低容量和MICT对代谢综合征患者是安全的。我们建议在两种训练之前进行肌肉调节计划，下肢静脉功能不全的患者应避免在跑步机上进行HIIT-低容量训练。试验注册号NCT03087721。
