Pacifici G M, Bencini C, Rane A
Pharmacology. 1986;32(5):283-91. doi: 10.1159/000138181.
Acetyltransferase with p-aminobenzoic acid (PABA) as substrate was investigated in the cytosolic fraction of the placenta, liver, adrenals, lungs, kidneys, intestine from human fetuses and the liver, lungs, kidneys and intestinal mucosa from adult subjects. All tissue specimens assayed catalyzed the acetylation of PABA at a significant rate. The activity (expressed as nmol of product formed/min/mg protein; mean +/- SE) was 1.10 +/- 0.59 in the fetal liver, 0.66 +/- 0.04 in the placental and 3.87 +/- 0.53 in the adult liver cytosol. Among the fetal tissues, the adrenals had the highest (2.36 +/- 0.78) and the gut the lowest activity (0.71 +/- 0.11). The acetyltransferase activity (mean +/- SE) in the lungs, kidneys and intestinal mucosa from adult subjects was 1.19 +/- 0.15; 1.34 +/- 0.04 and 3.80 +/- 0.34, respectively.
以对氨基苯甲酸（PABA）为底物的乙酰转移酶在人胎儿的胎盘、肝脏、肾上腺、肺、肾脏、肠道以及成人的肝脏、肺、肾脏和肠黏膜的胞质部分进行了研究。所有检测的组织标本都能以显著速率催化PABA的乙酰化反应。活性（以每分钟每毫克蛋白质形成的产物纳摩尔数表示；平均值±标准误）在胎儿肝脏中为1.10±0.59，在胎盘中为0.66±0.04，在成人肝脏胞质中为3.87±0.53。在胎儿组织中，肾上腺的活性最高（2.36±0.78），肠道的活性最低（0.71±0.11）。成人的肺、肾脏和肠黏膜中的乙酰转移酶活性（平均值±标准误）分别为1.19±0.15、1.34±0.04和3.80±0.34。
