Yup'ik 阿拉斯加原住民习惯性摄入海洋衍生 n-3 PUFAs 与心血管代谢炎症特征呈负相关。
Habitual Intake of Marine-Derived n-3 PUFAs is Inversely Associated with a Cardiometabolic Inflammatory Profile in Yup'ik Alaska Native People.
机构信息
Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, OR, USA.
Department of Statistics, University of Alabama at Birmingham, Birmingham, AL, USA.
出版信息
J Nutr. 2022 Mar 3;152(3):844-855. doi: 10.1093/jn/nxab412.
BACKGROUND
The relationship between dietary n-3 PUFAs and the prevention of cardiometabolic diseases, including type 2 diabetes, is unresolved. Examination of the association between n-3 PUFAs and chronic low-grade inflammation in a population where many individuals have had an extremely high intake of marine mammals and fish throughout their lifespan may provide important clues regarding the impact of n-3 PUFAs on health.
OBJECTIVES
The aim of this study was to explore associations between concentrations of n-3 PUFAs resulting from habitual intake of natural food sources high in fish and marine mammals with immune biomarkers of metabolic inflammation and parameters of glucose regulation.
METHODS
A total of 569 Yup'ik Alaska Native adults (18-87 years old) were enrolled in this cross-sectional study between December 2016 and November 2019. The RBC nitrogen isotope ratio (NIR; 15N/14N) was used as a validated measure of n-3 PUFA intake to select 165 participant samples from the first and fourth quartiles of n-3 PUFA intakes. Outcomes included 38 pro- and anti-inflammatory cytokines and 8 measures of glucose homeostasis associated with type 2 diabetes risks. These outcomes were evaluated for their associations with direct measurements of EPA, DHA, and arachidonic acid in RBCs.
ANALYSIS
Linear regression was used to detect significant relationships with cytokines and n-3 PUFAs, adiposity, and glucose-related variables.
RESULTS
The DHA concentration in RBC membranes was inversely associated with IL-6 (β = -0.0066; P < 0.001); EPA was inversely associated with TNFα (β = -0.4925; P < 0.001); and the NIR was inversely associated with Monocyte chemoattractant protein-1 (MCP-1) (β = -0.8345; P < 0.001) and IL-10 (β = -1.2868; P < 0.001).
CONCLUSIONS
Habitual intake of marine mammals and fish rich in n-3 PUFAs in this study population of Yup'ik Alaska Native adults is associated with reduced systemic inflammation, which may contribute to the low prevalence of diseases in which inflammation plays an important role.
背景
膳食 n-3 多不饱和脂肪酸与心脏代谢疾病（包括 2 型糖尿病）的预防之间的关系尚未解决。在一生中摄入大量海洋哺乳动物和鱼类的人群中，检查 n-3 多不饱和脂肪酸与慢性低度炎症之间的关联可能为 n-3 多不饱和脂肪酸对健康的影响提供重要线索。
目的
本研究旨在探讨习惯性摄入富含鱼类和海洋哺乳动物的天然食物来源所产生的 n-3 多不饱和脂肪酸浓度与代谢炎症的免疫生物标志物和葡萄糖调节参数之间的关联。
方法
本横断面研究共纳入 569 名Yup'ik 阿拉斯加原住民成年人（18-87 岁），于 2016 年 12 月至 2019 年 11 月期间入组。RBC 氮同位素比（NIR；15N/14N）用作 n-3 多不饱和脂肪酸摄入量的验证性测量指标，从 n-3 多不饱和脂肪酸摄入量的第一和第四四分位数中选择 165 名参与者样本。结果包括与 2 型糖尿病风险相关的 38 种促炎和抗炎细胞因子以及 8 种葡萄糖稳态测量指标。这些结果用于评估它们与 RBC 中 EPA、DHA 和花生四烯酸的直接测量值之间的关联。
分析
使用线性回归检测与细胞因子和 n-3 多不饱和脂肪酸、肥胖和与葡萄糖相关的变量之间的显著关系。
结果
RBC 膜中的 DHA 浓度与 IL-6 呈负相关（β=-0.0066；P<0.001）；EPA 与 TNFα 呈负相关（β=-0.4925；P<0.001）；NIR 与单核细胞趋化蛋白-1（MCP-1）（β=-0.8345；P<0.001）和 IL-10（β=-1.2868；P<0.001）呈负相关。
结论
在本Yup'ik 阿拉斯加原住民成年人研究人群中，习惯性摄入富含 n-3 多不饱和脂肪酸的海洋哺乳动物和鱼类与全身性炎症减轻有关，这可能有助于降低炎症发挥重要作用的疾病的患病率。
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