From the Global Health Research Center, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China (J.L., Q.Y., X.Y.).
Department of Epidemiology and Center for Global Cardiometabolic Health (J.L., K.H.K.C., T.E.M., T.Z., W.-C.W., Y.S., S.L.), School of Public Health, Brown University, Providence, RI.
Hypertension. 2022 Mar;79(3):518-531. doi: 10.1161/HYPERTENSIONAHA.121.18022. Epub 2021 Dec 7.
Early-life exposures play key roles in the development of metabolic diseases. Whether such effects exist beyond one generation remains unclear. This study aimed to determine the transgenerational association of early-life exposure to the Chinese famine of 1959 to 1962 with the trajectories of body mass index (BMI), waist circumference (WC), and blood pressure (BP) in 2 consecutive generations.
We included 21 106 F1 observations born between 1954 and 1967 (median age: 45 years) and 1926 F2 observations (median age: 23 years) from the longitudinal household-based China Health and Nutrition Survey from 1993 to 2015. Trajectories of BMI, WC, systolic BP, and diastolic BP were fitted and compared between groups using linear mixed effect models.
Early-life exposure to famine was associated with increased BMI, WC, and BP in 2 consecutive generations with sex and age disparities. In F1, famine was associated with increased BMI, WC, systolic BP, and diastolic BP, especially in men or those aged older than 50 years ( ranged from <0.001 to 0.02). In F2 men but not women, the parental exposure to famine was associated with 0.59 kg/m ([95% CI, 0.10-1.08], =0.02) increase in BMI. In F2 aged ≥25 years but not those younger ones, the parental exposure to famine was associated with increased BMI (0.83 kg/m [0.14-1.51], =0.03), systolic BP (2.04 mm Hg [0.20-3.88], =0.03), and diastolic BP (1.73 mm Hg [0.28-3.18], =0.02).
The effects of an adverse developmental environment through famine in early life on BMI and BP later in life may persist beyond one generation.
生命早期的暴露对代谢疾病的发展起着关键作用。这种影响是否会持续到下一代尚不清楚。本研究旨在确定生命早期暴露于 1959 年至 1962 年中国大饥荒与连续两代人体重指数（BMI）、腰围（WC）和血压（BP）轨迹之间的跨代关联。
我们纳入了 1993 年至 2015 年纵向家庭为基础的中国健康与营养调查中 21106 名 F1 观察（出生于 1954 年至 1967 年；中位年龄：45 岁）和 1926 名 F2 观察（出生于 1923 年至 1947 年；中位年龄：23 岁）。使用线性混合效应模型比较两组之间 BMI、WC、收缩压和舒张压的轨迹。
生命早期暴露于饥荒与连续两代人的 BMI、WC 和 BP 增加有关，存在性别和年龄差异。在 F1 中，饥荒与 BMI、WC、收缩压和舒张压的增加有关，尤其是在男性或年龄大于 50 岁的人群中（范围从 <0.001 至 0.02）。在 F2 男性中但不是女性中，父母暴露于饥荒与 BMI 增加 0.59kg/m（95%CI，0.10-1.08）有关，=0.02。在 F2 年龄≥25 岁但不是年龄较小的人群中，父母暴露于饥荒与 BMI 增加（0.83kg/m [0.14-1.51]），=0.03）、收缩压（2.04mmHg [0.20-3.88]）和舒张压（1.73mmHg [0.28-3.18]）有关，=0.03。
生命早期不良发育环境对 BMI 和 BP 的影响可能会持续到下一代。
