MM College of Pharmacy Maharishi Markandeshwar University, Mullana, Haryana 133207, India.
MM College of Pharmacy Maharishi Markandeshwar University, Mullana, Haryana 133207, India.
Biomed Pharmacother. 2022 Jan;145:112305. doi: 10.1016/j.biopha.2021.112305. Epub 2021 Dec 3.
Diabetes has become more common in recent years worldwide, and this growth is projected to continue in the future. The primary concern with diabetes is developing various complications, which significantly contribute to the disease's mortality and morbidity. Over time, the condition progresses from the pre-diabetic to the diabetic stage and then to the development of complications. Years and enormous resources are required to evaluate pharmacological interventions to prevent or delay the progression of disease or complications in humans. Appropriate screening models are required to gain a better understanding of both pathogenesis and potential therapeutic agents. Different species of animals are used to evaluate the pharmacological potentials and study the pathogenesis of the disease. Animal models are essential for research because they represent most of the structural, functional, and biochemical characteristics of human diseases. An ideal screening model should mimic the pathogenesis of the disease with identifiable characteristics. A thorough understanding of animal models is required for the experimental design to select an appropriate model. Each animal model has certain advantages and limitations. The present manuscript describes the animal models and their diagnostic characteristics to evaluate microvascular diabetic complications.
近年来，糖尿病在全球范围内变得越来越普遍，预计未来这种增长趋势还将持续。糖尿病的主要关注点是出现各种并发症，这对疾病的死亡率和发病率有重大影响。随着时间的推移，病情从糖尿病前期发展到糖尿病阶段，然后发展为并发症。评估药物干预措施以预防或延缓疾病或并发症的进展需要数年时间和大量资源。需要适当的筛选模型来更好地了解发病机制和潜在的治疗药物。不同种类的动物被用于评估药物潜力和研究疾病的发病机制。动物模型对于研究至关重要，因为它们代表了人类疾病的大多数结构、功能和生化特征。理想的筛选模型应该具有可识别的特征，模拟疾病的发病机制。为了进行实验设计以选择合适的模型，需要对动物模型有透彻的了解。每个动物模型都有一定的优点和局限性。本文描述了评估微血管糖尿病并发症的动物模型及其诊断特征。
