松果体卵黄囊瘤产生的 α-胎蛋白通过 68Ga-FAPI PET/MRI 检测到。

Pineal Yolk Sac Tumor Producing α-Fetoprotein Detected by 68Ga-FAPI PET/MRI.

机构信息

From the Departments of Nuclear Medicine & Minnan PET Center.

PET Center, Huashan Hospital.

出版信息

Clin Nucl Med. 2022 Jan 1;47(1):90-92. doi: 10.1097/RLU.0000000000003752.

DOI:10.1097/RLU.0000000000003752

PMID:34874353

Abstract

Pineal yolk sac tumors (YSTs) are a rare type of extragonadal YST. They make up a small fraction of all intracranial germ cell tumors and an even small fraction of pineal masses overall. This study reported a case of pineal YST with α-fetoprotein production revealed by 18F-FDG and 68Ga-FAPI PET/MRI. In the PET images, 68Ga-FAPI showed a far better tumor-to-background ratio than 18F-FDG in the pineal YST because there is little 68Ga-FAPI uptake in the brain. This case indicates that 68Ga-FAPI PET/MRI may be a useful tool for evaluating intracranial YST and other types of tumors in central nervous system.

摘要

松果体卵黄囊瘤（YST）是一种罕见的颅外 YST。它们在所有颅内生殖细胞瘤中所占比例很小，在整个松果体肿块中所占比例更小。本研究报告了一例松果体 YST 的病例，该病例通过 18F-FDG 和 68Ga-FAPI PET/MRI 显示出甲胎蛋白的产生。在 PET 图像中，由于大脑中几乎没有 68Ga-FAPI 摄取，因此 68Ga-FAPI 在松果体 YST 中的肿瘤与背景的比值远高于 18F-FDG。该病例表明，68Ga-FAPI PET/MRI 可能是评估颅内 YST 和中枢神经系统其他类型肿瘤的有用工具。