Tanaka Ryo, Hirata Yuki, Kojima Masahiro, Yoshino Tatsuhiko, Matsunaga Shigeki
Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo 060-0812, Japan.
Global Station for Biosurfaces and Drug Discovery, Hokkaido University, Sapporo 060-0812, Japan.
Chem Commun (Camb). 2021 Dec 21;58(1):76-79. doi: 10.1039/d1cc05956d.
The C-H bond addition reaction of 2-phenylpyridine derivatives with α,β-unsaturated carboxylic acids catalyzed by Cp*Rh(III)/BH·SMe is reported. Activation of C-H bonds with the rhodium catalyst and activation of α,β-unsaturated carboxylic acids with the boron catalyst cooperatively work, and a BINOL-urea hybrid ligand significantly improved the reactivity. With the optimized hybrid catalytic system, various β-disubstituted carboxylic acids were obtained under mild reaction conditions.
报道了由Cp*Rh(III)/BH·SMe催化的2-苯基吡啶衍生物与α,β-不饱和羧酸的C-H键加成反应。铑催化剂对C-H键的活化与硼催化剂对α,β-不饱和羧酸的活化协同作用，并且一种联萘酚-脲杂化配体显著提高了反应活性。使用优化后的杂化催化体系，在温和的反应条件下得到了各种β-二取代羧酸。
