Shchepankevich L A, Nikolaev Yu A, Taneeva E V, Pervuninskaya M A, Shchepankevich M S
Federal Research Center of Fundamental and Translational Medicine, Novosibirsk, Russia.
Novosibirsk State Medical University, Novosibirsk, Russia.
Zh Nevrol Psikhiatr Im S S Korsakova. 2021;121(10):32-37. doi: 10.17116/jnevro202112110132.
To study the efficacy and safety of sequential MexidoL therapy, administered intravenously (500 mg once a day) for 14 days, followed by taking the oral form Mexidol FORTE 250 at a dose of 250 mg (1 tablet) 3 times a day for 60 days in elderly patients with chronic cerebral ischemia (CCI) on the background of arterial hypertension and atherosclerosis.
An open prospective observational study included 60 patients with an established diagnosis (CCI), confirmed by the results of neuroimaging. All patients were examined with an assessment of neuropsychological status (MoCA test), severity of asthenia (scale MFI-20), emotional state (Hamilton anxiety and depression scale), motor functions (formalized clinical scale for assessing motor activity of elderly Tinetti). The effectiveness of the therapy was evaluated according to the quality of life questionnaire (SF-36).
The results of the study showed the high efficiency and safety of sequential therapy with Mexidol in relation to the relief of asthenic and emotional disorders, improving the state of cognitive functions, improving the quality of life of patients. The maximum effect occurred after the end of the full course of therapy. High adherence of patients to the therapy, low frequency of adverse events are shown.
Sequential use of intravenous administration of Mexidol followed by oral administration of Mexidol FORTE 250 is an effective and safe way to treat patients with CCI.
研究在动脉高血压和动脉粥样硬化背景下，对老年慢性脑缺血（CCI）患者采用序贯美西多宁疗法的疗效和安全性，即先静脉注射（每日一次，每次500毫克），持续14天，然后口服美西多宁强效片250毫克（1片），每日3次，持续60天。
一项开放性前瞻性观察研究纳入了60例经神经影像学结果确诊为CCI的患者。所有患者均接受了神经心理状态评估（蒙特利尔认知评估量表测试）、虚弱严重程度评估（MFI-20量表）、情绪状态评估（汉密尔顿焦虑和抑郁量表）以及运动功能评估（评估老年人运动活动的正式临床量表Tinetti量表）。根据生活质量问卷（SF-36）评估治疗效果。
研究结果表明，美西多宁序贯疗法在缓解虚弱和情绪障碍、改善认知功能状态、提高患者生活质量方面具有高效性和安全性。最大疗效出现在整个疗程结束后。患者对治疗的依从性高，不良事件发生率低。
先静脉注射美西多宁，然后口服美西多宁强效片250毫克的序贯使用方法是治疗CCI患者的一种有效且安全的方法。
