对加利福尼亚南部 2020-2021 年冬季激增期间单个大型卫生系统中通过基因组监测进行的 SARS-CoV-2 Epsilon 变体和住院情况的调查。
Investigation of SARS-CoV-2 Epsilon Variant and Hospitalization Status by Genomic Surveillance in a Single Large Health System During the 2020-2021 Winter Surge in Southern California.
机构信息
Department of Pathology and Laboratory Medicine, UCLA David Geffen School of Medicine, Los Angeles, CA, USA.
Los Angeles Department of Public Health, Downey, CA, USA.
出版信息
Am J Clin Pathol. 2022 May 4;157(5):649-652. doi: 10.1093/ajcp/aqab203.
Abstract
OBJECTIVES
This study aimed to assess whether the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Epsilon variant (B.1.429/427) is more virulent, leading to more hospitalization and more severe disease requiring intensive care unit (ICU) admission.
METHODS
SARS-CoV-2 genomic surveillance was performed on respiratory samples from 231 unique patients, collected at a single large health system in Southern California between November 2020 and March 2021 during the winter surge.
RESULTS
The frequencies of the Epsilon variant among outpatients, hospitalized patients, and ICU patients were indifferent.
CONCLUSIONS
Our study suggests that the Epsilon variant is not associated with increased hospitalization and ICU admission.
摘要
目的
本研究旨在评估严重急性呼吸综合征冠状病毒 2 （SARS-CoV-2）Epsilon 变体（B.1.429/427）是否更具毒性，导致更多住院和更严重的疾病需要入住重症监护病房（ICU）。
方法
对 2020 年 11 月至 2021 年 3 月冬季高峰期间在加利福尼亚州南部单一大型卫生系统采集的 231 例呼吸道样本进行了 SARS-CoV-2 基因组监测。
结果
Epsilon 变体在门诊患者、住院患者和 ICU 患者中的频率没有差异。
结论
我们的研究表明，Epsilon 变体与住院和 ICU 入院率增加无关。
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