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Impaired ACE2 glycosylation and protease activity lowers COVID-19 susceptibility in Gitelman's and Bartter's syndromes.

作者信息

Bertoldi Giovanni, Ravarotto Verdiana, Sgarabotto Luca, Davis Paul A, Gobbi Laura, Calò Lorenzo A

机构信息

Nephrology, Dialysis and Transplantation Unit, Department of Medicine, University of Padova, Padova, Italy.

Department of Nutrition, University of California, Davis, California, USA.

出版信息

J Intern Med. 2022 Apr;291(4):522-524. doi: 10.1111/joim.13426. Epub 2021 Dec 16.

DOI:10.1111/joim.13426
PMID:34875124
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9414342/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f986/9414342/a5e4d3a26804/JOIM-291-522-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f986/9414342/a5e4d3a26804/JOIM-291-522-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f986/9414342/a5e4d3a26804/JOIM-291-522-g001.jpg

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Impaired ACE2 glycosylation and protease activity lowers COVID-19 susceptibility in Gitelman's and Bartter's syndromes.血管紧张素转换酶2（ACE2）糖基化受损和蛋白酶活性降低会降低吉特曼综合征和巴特综合征患者对新型冠状病毒肺炎（COVID-19）的易感性。
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Are the Clinical Presentations (Phenotypes) of Gitelman's and Bartter's Syndromes Gene Mutations Driven by Their Effects on Intracellular pH, Their "pH" Enotype?Gitelman 综合征和 Bartter 综合征的临床表型（表型）是否由其对细胞内 pH 的影响，即它们的“pH 表型”所驱动的？
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本文引用的文献

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ACE2 and SARS-CoV-2 Infection Risk: Insights From Patients With Two Rare Genetic Tubulopathies, Gitelman's and Bartter's Syndromes.血管紧张素转换酶2（ACE2）与新型冠状病毒2型（SARS-CoV-2）感染风险：来自吉特曼综合征和巴特综合征这两种罕见遗传性肾小管疾病患者的见解
Front Med (Lausanne). 2021 May 4;8:647319. doi: 10.3389/fmed.2021.647319. eCollection 2021.
2
Association Between Renin-Angiotensin-Aldosterone System Inhibitors and Clinical Outcomes in Patients With COVID-19: A Systematic Review and Meta-analysis.血管紧张素-肾素-醛固酮系统抑制剂与 COVID-19 患者临床结局的相关性：系统评价和荟萃分析。
JAMA Netw Open. 2021 Mar 1;4(3):e213594. doi: 10.1001/jamanetworkopen.2021.3594.
3
新冠病毒19、帕罗韦德以及来自对SARS-CoV-2感染具有天然抵抗力的罕见遗传病的教训。
J Nephrol. 2023 Apr;36(3):925-927. doi: 10.1007/s40620-022-01439-1. Epub 2022 Sep 16.
4
Angiotensin II, RAS Activation, and RAS Blockers in COVID-19: Unambiguous Evidence.血管紧张素II、肾素-血管紧张素系统激活与肾素-血管紧张素系统阻滞剂在2019冠状病毒病中的作用：确凿证据
Kidney Blood Press Res. 2022;47(10):593-596. doi: 10.1159/000526791. Epub 2022 Sep 5.
5
Gitelman's and Bartter's Syndromes: From Genetics to the Molecular Basis of Hypertension and More.吉特曼综合征和巴特综合征：从遗传学角度看高血压及其他更多疾病的分子基础。
Kidney Blood Press Res. 2022;47(9):556-564. doi: 10.1159/000526070. Epub 2022 Jul 20.
Are patients with hypertension and diabetes mellitus at increased risk for COVID-19 infection?
高血压和糖尿病患者感染新型冠状病毒肺炎（COVID-19）的风险会增加吗？
Lancet Respir Med. 2020 Apr;8(4):e21. doi: 10.1016/S2213-2600(20)30116-8. Epub 2020 Mar 11.
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Science. 2020 Mar 27;367(6485):1444-1448. doi: 10.1126/science.abb2762. Epub 2020 Mar 4.
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Cellular entry of the SARS coronavirus.严重急性呼吸综合征冠状病毒的细胞进入
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