Xu Jun, Cai Heng, Shen Jiabin, Shen Chao, Wu Jie, Zhang Pengfei, Liu Xiaogang
Department of Chemistry, National University of Singapore, Singapore 117543, Singapore.
Center for Functional Materials, National University of Singapore Suzhou Research Institute, Suzhou 215123, China.
J Org Chem. 2021 Dec 17;86(24):17816-17832. doi: 10.1021/acs.joc.1c02125. Epub 2021 Dec 7.
We report a Minisci-type cross-dehydrogenative alkylation in an aerobic atmosphere using abundant and inexpensive cerium chloride as a photocatalyst and air as an oxidant. This photoreaction exhibits excellent tolerance to functional groups and is suitable for both heteroarene and alkane substrates under mild conditions, generating the corresponding products in moderate-to-good yields. Our method provides an alternative approach for the late-stage functionalization of valuable substrates.
我们报道了一种在有氧气氛中进行的Minisci型交叉脱氢烷基化反应，该反应使用丰富且廉价的氯化铈作为光催化剂，空气作为氧化剂。这种光反应对官能团具有出色的耐受性，在温和条件下适用于杂芳烃和烷烃底物，能以中等到良好的产率生成相应产物。我们的方法为有价值底物的后期官能团化提供了一种替代方法。
