Borgogno Pamela, Fernández Pehuén, Douthat Walter, de Arteaga Javier, Damonte Juan Carlos, Giacomi Virginia, de la Fuente Jorge, Chiurchiu Carlos
Servicio de Nefrología, Hospital Privado Universitario de Córdoba, Argentina. E-mail:
Universidad Católica de Córdoba, Argentina.
Medicina (B Aires). 2021;81(6):986-995.
The ABO incompatible (ABOi) living donor (LD) kidney transplant allows increasing the number of donors and reducing the time on the waiting list. The objectives of this study were to compare graft survival, patient survival, rejection risk factors and complications during the first year p ost-transplantation in patients who received an ABOi LD kidney transplant between 2014 and 2019 in our institution, matched according to sex, age and immunological risk with a control group of ABO compatible (ABOc) LD kidney transplants in the same period. Thirteen patients were included in each group. No significant differences were found between ABOi and ABOc in the incidence of delayed graft function (n = 0 vs. 1), bleeding (0 vs. 0), infections (13 vs. 13), cellular rejection (1 vs. 3) and humoral rejection (4 vs. 3) in the first year after transplantation. The rejection rate in ABOi do not seem to be related to blood incompatibility. No risk factors associated with rejection were found. Overall survival of patients was 100% in both groups, and graft survival was 92.3% in ABOi and 100% in ABOc (p = 1). ABOi kidney transplantation is an adequate feasible option in our environment for those who do not have compatible donors.
ABO血型不相容(ABOi)的活体供者(LD)肾移植能够增加供者数量并缩短等待名单上的时间。本研究的目的是比较2014年至2019年在我们机构接受ABOi LD肾移植的患者在移植后第一年的移植物存活、患者存活、排斥风险因素和并发症,并根据性别、年龄和免疫风险与同期ABO相容(ABOc)LD肾移植的对照组进行匹配。每组纳入13例患者。移植后第一年,ABOi组和ABOc组在移植肾功能延迟恢复发生率(n = 0 vs. 1)、出血(0 vs. 0)、感染(13 vs. 13)、细胞性排斥(1 vs. 3)和体液性排斥(4 vs. 3)方面未发现显著差异。ABOi组的排斥率似乎与血型不相容无关。未发现与排斥相关的风险因素。两组患者的总体生存率均为100%,ABOi组的移植物存活率为92.3%,ABOc组为100%(p = 1)。对于没有相容供者的患者,ABOi肾移植在我们的环境中是一种合适的可行选择。