Steplewski Z, Vogel W H
Life Sci. 1986 Jun 30;38(26):2419-27. doi: 10.1016/0024-3205(86)90611-9.
Rats were stressed by immobilization for 3 hrs daily for 11 days and either sacrificed immediately after the last stress session (chronic stress group) or allowed to recover for 12 days and then sacrificed (recovery group). After 11 days of stress, leukocytes and lymphocytes were significantly decreased and neutrophils and large granular lymphocytes were markedly increased. The number of total, helper and suppressor T cells was significantly decreased but the percentage of T cells remained unchanged. Natural Killer (NK) cell activity was unaffected. After a 12 day recovery period from stress, the number of leukocytes returned to normal but the percentage of neutrophils was now below baseline whereas the percentages of lymphocytes and large granular lymphocytes had increased significantly. The number and percentage of total T cells and helper T cells was enhanced and NK cell activity tended to be increased. Thus, chronic stress as well as recovery from stress can affect individual components of the cellular immune system quite selectively and differently. In addition, a comparison of the effects of stress seen in this study with healthy rats with those seen under identical conditions in tumor bearing rats shows that stress or recovery from stress can affect the immune system differently in healthy or tumor bearing animals.
大鼠连续11天每天被束缚3小时以造成应激，在最后一次应激结束后，一组大鼠立即被处死（慢性应激组），另一组大鼠被允许恢复12天然后处死（恢复组）。应激11天后，白细胞和淋巴细胞显著减少，中性粒细胞和大颗粒淋巴细胞显著增加。总T细胞、辅助性T细胞和抑制性T细胞数量显著减少，但T细胞百分比保持不变。自然杀伤（NK）细胞活性未受影响。应激12天恢复期后，白细胞数量恢复正常，但中性粒细胞百分比低于基线水平，而淋巴细胞和大颗粒淋巴细胞百分比显著增加。总T细胞和辅助性T细胞的数量和百分比增加，NK细胞活性有增加趋势。因此，慢性应激以及应激后的恢复可以相当有选择性且不同地影响细胞免疫系统的各个组成部分。此外，将本研究中在健康大鼠身上观察到的应激效应与在相同条件下荷瘤大鼠身上观察到的效应进行比较，结果表明，应激或应激后的恢复在健康动物或荷瘤动物身上对免疫系统的影响有所不同。
