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一名接受醋硝香豆素治疗瓣膜性心房颤动的患者发生自发性脊髓硬膜外血肿:一例罕见病例报告。

Spontaneous spinal epidural hematoma in a patient on acenocoumarol for valvular atrial fibrillation: A rare case report.

作者信息

El-Azrak Mohammed, Noumairi Mohammed, Oulalite Mohammed Amine, El Mir Siham, Kachmar Safaa, Bkiyar Houssam, El Ouafi Noha, El Oumri Ahmed Amine, Bazid Zakaria, Housni Brahim

机构信息

Department of Cardiology, Mohammed VI University Hospital, Faculty of Medicine and Pharmacy of Oujda, Mohammed First University, Oujda, Morocco.

Department of Physical Medicine and Rehabilitation, Mohammed VI University Hospital, Faculty of Medicine and Pharmacy of Oujda, Mohammed First University, Oujda, Morocco.

出版信息

Ann Med Surg (Lond). 2021 Nov 17;72:103076. doi: 10.1016/j.amsu.2021.103076. eCollection 2021 Dec.

Abstract

INTRODUCTION

Spontaneous spinal epidural hematoma (SSEH) is a rare finding, but one with serious clinical implications. Oral anticoagulant drugs are known to be associated with the SSEH onset, particularly when combined with drugs increasing the bleeding risk.

CASE PRESENTATION

We present the case of a 62-year-old female on acencoumarol for her atrial fibrillation complicating severe mitral stenosis with a history of Ketoprofen use for the onset of her first symptoms. She presented to our emergency room with paraplegia and sphincter disturbance. Spinal magnetic resonance imaging (MRI) revealed a posterior SSEH extended from T10 to T12 requiring an urgent decompression of the spinal cord by laminectomy performed within 48 hours from the symptom's onset. After 3 months of rehabilitation, the patient improves partially her muscular strength with mostly unchanged sensitive and sphincteric levels.

CLINICAL DISCUSSION

Vitamin K antagonists (VKA) use appears to be a high suspicion index for SSEH diagnosis resulting in earlier surgery and improving neurological outcome. Also, it is important to pay attention to the concomitant use of VKA and non-steroidal anti-inflammatory drugs which increase the risk of bleeding and may worsen the neurological outcome.

CONCLUSION

SSEH is a rare and serious finding which should be especially searched when a history of oral anticoagulation is reported in presence of neurological symptoms. A prompt and suitable management may improve the patient outcomes.

摘要

引言

自发性脊髓硬膜外血肿(SSEH)是一种罕见的病症,但具有严重的临床意义。已知口服抗凝药物与SSEH的发病有关,尤其是与增加出血风险的药物联合使用时。

病例报告

我们报告一例62岁女性,因心房颤动服用醋硝香豆素,同时患有严重二尖瓣狭窄,首次出现症状时曾使用酮洛芬。她因截瘫和括约肌功能障碍就诊于我们的急诊室。脊髓磁共振成像(MRI)显示,一个从T10延伸至T12的后方SSEH,需要在症状出现后48小时内通过椎板切除术对脊髓进行紧急减压。经过3个月的康复治疗,患者的肌肉力量部分恢复,感觉和括约肌功能水平基本未变。

临床讨论

维生素K拮抗剂(VKA)的使用似乎是SSEH诊断的一个高可疑指标,这会导致更早进行手术并改善神经功能预后。此外,重要的是要注意VKA与非甾体抗炎药的联合使用,这会增加出血风险并可能使神经功能预后恶化。

结论

SSEH是一种罕见且严重的病症,当报告有口服抗凝病史且出现神经症状时应特别排查。及时且恰当的处理可能会改善患者的预后。

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