Walker Macey L, Patel Keshav, Li Tong, Kassir Mahmoud
Internal Medicine, Western Michigan University Homer Stryker M.D. School of Medicine, Kalamazoo, USA.
Internal Medicine, University of Illinois College of Medicine, Chicago, USA.
Cureus. 2021 Nov 30;13(11):e20056. doi: 10.7759/cureus.20056. eCollection 2021 Nov.
Opioid-associated amnestic syndrome (OAS) is a relatively new condition that is associated with opioid abuse and has increased in prevalence since the notable rise in opioid-related deaths and opioid-related hospitalizations of the opioid crisis. Patients often present with acute anterograde amnesia and current opioid abuse, most commonly fentanyl. OAS is frequently diagnosed when other potentially infectious or metabolic conditions such as encephalitis and seizures are ruled out, as these conditions can also present similarly to OAS. This case highlights the signs, symptoms, and hallmark characteristics of OAS, including bilateral hippocampal edema and anterograde amnesia.
阿片类药物相关性遗忘综合征（OAS）是一种相对较新的病症，与阿片类药物滥用有关，自阿片类药物危机导致阿片类药物相关死亡和阿片类药物相关住院人数显著上升以来，其患病率有所增加。患者常表现为急性顺行性遗忘和当前的阿片类药物滥用，最常见的是芬太尼。当排除其他潜在的感染性或代谢性疾病，如脑炎和癫痫发作时，常可诊断为OAS，因为这些疾病也可能表现出与OAS相似的症状。本病例突出了OAS的体征、症状和标志性特征，包括双侧海马体水肿和顺行性遗忘。
