Huang Deborah, Lukas Rimas V
Neurology, Northwestern University, Feinberg School of Medicine, Chicago, USA.
Neuro-Oncology, Lou Malnati Brain Tumor Institute, Chicago, USA.
Cureus. 2021 Jan 12;13(1):e12651. doi: 10.7759/cureus.12651.
The hippocampus is a crucial component of the circuits involved in memory formation and recall. Bilateral hippocampal lesions can lead to profound anterograde amnesia. As a highly vascularized structure, the hippocampus is susceptible to ischemia from hypoxic and toxic insults. Infarction of bilateral hippocampi as a result of cocaine use, while rare, is well described in the literature. Combined opiate and stimulant abuse also cause dysfunction of this structure. We present a case of complete bilateral hippocampal diffusion restriction and anterograde amnesia after heroin, cocaine, and benzodiazepine abuse, consistent with opioid-associated amnestic syndrome, as well as a remarkable resolution of amnesia months later.
海马体是参与记忆形成和回忆的神经回路的关键组成部分。双侧海马体损伤可导致严重的顺行性遗忘。作为一个血管高度丰富的结构，海马体易受缺氧和毒性损伤引起的缺血影响。因使用可卡因导致双侧海马体梗死虽罕见，但在文献中有充分描述。阿片类药物和兴奋剂联合滥用也会导致该结构功能障碍。我们报告一例在滥用海洛因、可卡因和苯二氮卓类药物后出现双侧海马体完全性弥散受限和顺行性遗忘的病例，符合阿片类药物相关遗忘综合征，且数月后遗忘症状有显著缓解。
