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巨大局灶性结节性增生对动脉栓塞无反应:一例报告。

Large focal nodular hyperplasia is unresponsive to arterial embolization: A case report.

作者信息

Ren Hui, Gao Yin-Jie, Ma Xue-Mei, Zhou Shao-Tang

机构信息

Department of Hepatobiliary and Liver Transplant Center, The Fifth Medical Center, Chinese People's Liberation Army General Hospital, Beijing 100039, China.

出版信息

World J Clin Cases. 2021 Nov 16;9(32):9977-9981. doi: 10.12998/wjcc.v9.i32.9977.

DOI:10.12998/wjcc.v9.i32.9977
PMID:34877339
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8610892/
Abstract

BACKGROUND

Focal nodular hyperplasia (FNH) commonly occurs in women; it is usually asymptomatic and sometimes difficult to differentiate from hepatocellular carcinoma (HCC).

CASE SUMMARY

A large space-occupying lesion in the right lobe of the liver was incidentally detected in an adult man and diagnosed as HCC. Transcatheter arterial chemoembolization was applied once monthly for 2 years, but the lesion did not decrease in size. It was revealed by biopsy to be FNH. Eleven years later, the patient underwent liver resection due to hemorrhage and the pathological examination confirmed FNH.

CONCLUSION

For a space-occupying lesion, it is prerequisite to pathologically confirm the diagnosis and the corresponding intervention can be effective.

摘要

背景

局灶性结节性增生(FNH)常见于女性;通常无症状,有时难以与肝细胞癌(HCC)鉴别。

病例摘要

一名成年男性偶然发现肝脏右叶有一个大的占位性病变,诊断为HCC。每月进行一次经动脉化疗栓塞,持续2年,但病变大小未减小。活检显示为FNH。11年后,患者因出血接受肝切除术,病理检查确诊为FNH。

结论

对于占位性病变,病理确诊是前提,相应的干预才可能有效。

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本文引用的文献

1
Near-Complete Disappearance of a Giant Focal Nodular Hyperplasia in the Liver.肝脏巨大局灶性结节性增生几乎完全消失
Clin Gastroenterol Hepatol. 2021 Apr;19(4):e34. doi: 10.1016/j.cgh.2020.02.016. Epub 2020 Feb 14.
2
Surgical indications for focal nodular hyperplasia of the liver: Single-center experience of 48 adult cases.肝脏局灶性结节性增生的手术指征:48例成人病例的单中心经验
Ann Hepatobiliary Pancreat Surg. 2019 Feb;23(1):8-12. doi: 10.14701/ahbps.2019.23.1.8. Epub 2019 Feb 28.
3
Value of Texture Analysis on Gadoxetic Acid-Enhanced MRI for Differentiating Hepatocellular Adenoma From Focal Nodular Hyperplasia.
钆塞酸增强 MRI 纹理分析在鉴别肝细胞腺瘤与局灶性结节增生中的价值。
AJR Am J Roentgenol. 2019 Mar;212(3):538-546. doi: 10.2214/AJR.18.20182. Epub 2018 Dec 17.
4
What is Changing in Indications and Treatment of Focal Nodular Hyperplasia of the Liver. Is There Any Place for Surgery?肝脏局灶性结节性增生的指征和治疗正在发生哪些变化?手术还有存在的意义吗?
Ann Hepatol. 2017 May-Jun;16(3):333-341. doi: 10.5604/16652681.1235475.
5
Transarterial embolization with bleomycin for symptomatic hepatic focal nodular hyperplasia.使用博来霉素经动脉栓塞治疗有症状的肝脏局灶性结节性增生。
Diagn Interv Radiol. 2017 Jan-Feb;23(1):66-70. doi: 10.5152/dir.2016.16061.
6
Focal nodular hyperplasia: a review of current indications for and outcomes of hepatic resection.局灶性结节性增生:肝切除术当前适应证和结果的综述。
HPB (Oxford). 2014 Jun;16(6):503-11. doi: 10.1111/hpb.12169. Epub 2013 Oct 15.
7
Focal Nodular Hyperplasia and Hepatocellular Adenoma around the World Viewed through the Scope of the Immunopathological Classification.通过免疫病理分类视角看世界各地的局灶性结节性增生和肝细胞腺瘤
Int J Hepatol. 2013;2013:268625. doi: 10.1155/2013/268625. Epub 2013 Apr 14.
8
Hepatocellular benign tumors-from molecular classification to personalized clinical care.肝细胞良性肿瘤——从分子分类到个体化临床治疗。
Gastroenterology. 2013 May;144(5):888-902. doi: 10.1053/j.gastro.2013.02.032. Epub 2013 Feb 26.
9
Focal nodular hyperplasia or focal nodular hyperplasia-like lesions of the liver: a special emphasis on diagnosis.肝脏局灶性结节性增生或局灶性结节样增生样病变:特别强调诊断。
J Gastroenterol Hepatol. 2011 Jun;26(6):1004-9. doi: 10.1111/j.1440-1746.2011.06659.x.
10
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J Vasc Interv Radiol. 2009 Apr;20(4):543-7. doi: 10.1016/j.jvir.2009.01.001.